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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dextro-naloxone counteracts amphetamine-induced hyperactivity.
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Dextro-naloxone counteracts amphetamine-induced hyperactivity.

机译：右旋纳洛酮抵消了苯丙胺诱导的过度活跃。

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摘要

The locomotor stimulating effect of d-amphetamine in mice was counteracted by the administration of l-naloxone [(-)-naloxone], a known opiate receptor antagonist. Mice injected with amphetamine reached a peak locomotor activity within 30 min. When treated simultaneously with amphetamine and l-naloxone, these subjects showed low motility. Furthermore, when mice were treated not with l-naloxone but with its mirror image, d-naloxone [(+)-naloxone], a compound that by itself does not antagonize opiates and does not affect spontaneous motility, they showed no amphetamine-induced hyperactivity. The finding that an enantiomer of naloxone, with no opiate antagonist activity, is able to block the excitatory action of amphetamine, suggests the existence of a hitherto unknown mechanism of counteracting some of the effects of stimulants and euphoriants like amphetamine and cocaine.
机译：d-苯异丙胺对小鼠的运动刺激作用可通过服用一种已知的阿片受体拮抗剂1-纳洛酮[（-）-纳洛酮]来抵消。注射苯丙胺的小鼠在30分钟内达到峰值运动能力。当同时用苯丙胺和1-纳洛酮治疗时，这些受试者表现出低运动性。此外，当不对小鼠进行l-纳洛酮治疗而是对其镜像进行处理时，d-纳洛酮[（+）-纳洛酮]本身不会拮抗阿片类药物并且不会影响自发运动，因此它们不会显示苯丙胺诱导的多动症。纳洛酮的对映异构体没有鸦片拮抗剂的活性，能够阻止苯丙胺的兴奋作用，这一发现表明，存在迄今未知的抵消兴奋剂和欣快剂（如苯丙胺和可卡因）作用的机制。

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