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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Involvement of spinal NMDA receptors in capsaicin-induced nociception.
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Involvement of spinal NMDA receptors in capsaicin-induced nociception.

机译：脊髓NMDA受体参与辣椒素诱导的伤害感受。

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摘要

Intraplantar injection of capsaicin into the mouse hindpaw produced an acute nociceptive response. The involvement of N-methyl-D-aspartate (NMDA) receptors was examined by intrathecal administration of various excitatory amino acid (EAA) receptor antagonists. The selective and competitive NMDA receptor antagonists, D(-)-2-amino-5-phosphono-valeric acid (APV) and (+/-)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphoric acid (CPP), were most potent in inhibiting the nociceptive response induced by capsaicin (ED50, 0.23 nmol and 0.12 nmol). The noncompetitive NMDA receptor antagonist dizocilpine (MK-801) and the non-NMDA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) had similar effects on the capsaicin-induced nociception (ED50, 2.90 and 7.98 nmol), while ketamine and 7-chlorokynurenic acid were without effect. Ifenprodil, an antagonist at the receptor-coupled polyamine site, showed a significant reduction of the nociceptive response (ED50, 13.8 nmol). The inhibitory effects of APV, CPP, MK-801, and ifenprodil were reversed by co-administration of NMDA. Coadministration of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) or kainate resulted in a marked reduction of CNQX-induced antinociception. The present results suggest that the NMDA receptor plays a key role in spinal nociceptive processing as measured by the capsaicin test in mice. This nociceptive test may be useful for evaluating competitive NMDA antagonists.
机译：向小鼠后爪足内注射辣椒素会产生急性伤害反应。通过鞘内施用各种兴奋性氨基酸（EAA）受体拮抗剂检查了N-甲基-D-天冬氨酸（NMDA）受体的参与。选择性和竞争性NMDA受体拮抗剂D（-）-2-氨基-5-膦酰基戊酸（APV）和（+/-）-3-（2-羧基哌嗪-4-基）丙基-1-磷酸（CPP）最能抑制辣椒素（ED50、0.23 nmol和0.12 nmol）诱导的伤害反应。非竞争性NMDA受体拮抗剂地佐西平（MK-801）和非NMDA拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）对辣椒素诱导的伤害感受有相似的作用（ED50、2.90和7.98 nmol） ），而氯胺酮和7-氯尿嘧啶酸无效。 Ifenprodil（受体偶联的多胺位点的拮抗剂）显示出明显的伤害反应（ED50，13.8 nmol）。共同使用NMDA可逆转APV，CPP，MK-801和艾芬地尔的抑制作用。 α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸（AMPA）或海藻酸盐的共同给药导致CNQX诱导的抗伤害感受明显降低。目前的结果表明，NMDA受体在小鼠的辣椒素试验中在脊髓伤害感受过程中起着关键作用。此伤害性测试可能对评估竞争性NMDA拮抗剂有用。

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