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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >-)Ephedrine and caffeine mutually potentiate one another's amphetamine-like stimulus effects.
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-)Ephedrine and caffeine mutually potentiate one another's amphetamine-like stimulus effects.

机译：-）麻黄碱和咖啡因相互促进对方的苯丙胺样刺激作用。

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摘要

Using rats trained to discriminate 1 mg/kg of (+)amphetamine (ED50 = 0.4 mg/kg) from saline vehicle in a two-lever drug discrimination procedure, it was shown that (-)ephedrine (ED50 = 4.5 mg/kg), but not (+)ephedrine, substitutes for the (+)AMPH stimulus. It was also shown that caffeine (ED50 = 12.9 mg/kg) can substitute for (+)amphetamine in a dose-related fashion. Doses of (-)ephedrine and caffeine, which produced < or = 1% drug-appropriate responding when administered alone, were able to enhance each other's stimulus effects when administered in combination such that there was a twofold leftward shift in their respective dose-response curves. Furthermore, stimulus generalization occurred when a dose of caffeine that produced saline-appropriate responding when administered alone was administered in combination with (+)ephedrine. It would appear that low doses of (-)ephedrine and caffeine may mutually potentiate one another's stimulus effects in (+)AMPH-trained rats, and that a combination of caffeine and (+)ephedrine result in altered stimulus character when compared to comparable doses of either agent administered alone.
机译：使用训练有素的大鼠通过两杆药物区分程序从盐水媒介物中区分出1 mg / kg的（+）苯丙胺（ED50 = 0.4 mg / kg），结果表明，（-）麻黄碱（ED50 = 4.5 mg / kg） ，但（+）麻黄碱不能替代（+）AMPH刺激。还显示咖啡因（ED50 = 12.9 mg / kg）可以剂量相关的方式代替（+）苯丙胺。单独给药时产生（-）≤1％药物反应性的（-）麻黄碱和咖啡因剂量在组合给药时能够增强彼此的刺激作用，因此各自的剂量反应向左移动了两倍曲线。此外，当与（+）麻黄碱联合使用时，当一剂量的咖啡因单独给药时会产生生理盐水的反应时，就会产生刺激的普遍性。似乎低剂量的（-）麻黄碱和咖啡因可能在（+）AMPH训练的大鼠中相互增强对方的刺激作用，并且与可比较的剂量相比，咖啡因和（+）麻黄碱的组合会导致刺激特性改变单独施用的任何一种药物。

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