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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cocaine and alcohol synergism in taste aversion learning.
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Cocaine and alcohol synergism in taste aversion learning.

机译：可卡因和酒精在味觉厌恶学习中的协同作用。

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Female Long-Evans rats were given 20-min access to saccharin followed by injections of alcohol and cocaine, alone and in combination. Although there was no significant interaction between alcohol and cocaine when cocaine was given intraperitoneally (IP), aversions induced by the drug combination when cocaine was administered subcutaneously (SC) were significantly greater than those induced by either drug alone. Further, the aversions induced by the combination were significantly greater than the summed effects of the individual drugs administered alone, indicating a synergistic interaction between cocaine and alcohol. It was suggested that this synergism might result from a summation of the effects of alcohol, cocaine, and cocaethylene, a unique and toxic metabolite of cocaine produced when alcohol is coadministered. To assess the role of cocaethylene in the present design, additional taste aversion assessments were performed in which saccharin was paired with either IP or SC injections of cocaethylene. Although cocaethylene was found to induce aversions, the summed changes in consumption from baseline produced by cocaine, alcohol, and cocaethylene were significantly less than the changes produced by cocaine and alcohol in combination. These results indicate that the synergistic interaction between cocaine and alcohol in the present design cannot be attributed solely to summation of the effects of the individual drugs and the metabolite cocaethylene. Additional mechanisms by which cocaethylene might contribute to the synergistic interaction between cocaine and alcohol, as well as the role pharmacokinetic interactions between cocaine and alcohol might have in the interaction, were discussed.
机译：雌性Long-Evans大鼠可以单独或组合使用糖精20分钟，然后注射酒精和可卡因。尽管腹膜内（IP）注射可卡因时，酒精与可卡因之间没有显着的相互作用，但是皮下注射可卡因（SC）时，药物组合引起的厌恶明显大于单独使用这两种药物时所产生的厌恶。此外，由组合引起的厌恶感明显大于单独给药的单个药物的总和效应，表明可卡因与酒精之间存在协同作用。有人认为，这种协同作用可能是由于酒精，可卡因和可卡因的共同作用而产生的。可卡因和可卡因是并用酒精时产生的可卡因的一种独特而有毒的代谢产物。为了评估可口乙烯在本设计中的作用，进行了额外的口味厌恶评估，其中糖精与可口乙烯的IP或SC注射配对。尽管发现可卡因会引起厌恶，但可卡因，酒精和可卡因引起的基线消费量变化总和明显小于可卡因和酒精相结合产生的消费变化。这些结果表明，在本设计中可卡因与酒精之间的协同相互作用不能仅仅归因于各个药物和可卡因代谢物的作用之和。讨论了可卡因可能有助于可卡因与酒精之间的协同相互作用的其他机制，以及可卡因与酒精之间的药代动力学相互作用在相互作用中的作用。

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