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首页> 外文期刊>Pharmacology and Toxicology: An International Journal >Subchronic toxicity of Baltic herring oil and its fractions in the rat II: Clinical observations and toxicological parameters.
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Subchronic toxicity of Baltic herring oil and its fractions in the rat II: Clinical observations and toxicological parameters.

机译：波罗的海鲱鱼油及其馏分在大鼠中的亚慢性毒性II：临床观察和毒理学参数。

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This study aimed to increase the knowledge about the toxicity of fish-derived organohalogen pollutants in mammals. The strategy chosen was to separate organohalogen pollutants derived from Baltic herring (Clupea harengus) fillet, in order to obtain fractions with differing proportions of identified and unidentified halogenated pollutants, and to perform a subchronic toxicity study in rats, essentially according to the OECD guidelines, at three dose levels. Nordic Sea lodda (Mallotus villosus) oil, with low levels of persistent organohalogen pollutants, was used as an additional control diet. The toxicological examination showed that exposure to Baltic herring oil and its fractions at dose levels corresponding to a human intake in the range of 1.6 to 34.4 kg Baltic herring per week resulted in minimal effects. The spectrum of effects was similar to that, which is observed after low-level exposure to pollutants such as chlorinated dibenzo-p-dioxins and dibenzofurans (CDD/F) and chlorinated biphenyls, despite the fact that these contaminants contribute to a minor part of the extractable organically bound chlorine (EOCI). The study confirmed previous findings that induction of hepatic ethoxyresorufin deethylase (EROD) activity takes place at daily intake levels 0.15 ng fish-derived CDD/F-TEQs/kg body weight. The study also demonstrated that hepatic vitamin A reduction takes place at somewhat higher daily exposure levels, i.e. 0.16-0.30 ng fish-derived CDD/F-TEQs/kg body weight. Halogenated fatty acids, the major component of EOCI, could not be linked to any of the measured effects. From a risk management point of view, the study provides important new information of effect levels for Ah-receptor mediated responses following low level exposure to organohalogen compounds from a matrix relevant for human exposure.
机译：这项研究旨在增加关于鱼类中有机卤素污染物在哺乳动物中毒性的知识。所选择的策略是分离源自波罗的海鲱（Clupea harengus）鱼片的有机卤素污染物，以获得具有不同比例的已鉴定和未鉴定卤代污染物的馏分，并基本上根据OECD指南在大鼠中进行亚慢性毒性研究，在三个剂量水平。北欧海螯虾油（Mallotus villosus）油中持久性有机卤素污染物含量低，被用作额外的对照饮食。毒理学检查表明，按每周人摄入1.6至34.4 kg波罗的海鲱的剂量，暴露于波罗的海鲱鱼油及其馏分的影响最小。其影响范围与在低水平接触污染物（如氯化二苯并-对二恶英和二苯并呋喃（CDD / F）和氯化联苯）后观察到的相似，尽管这些污染物仅占污染物的一小部分。可萃取的有机结合氯（EOCI）。这项研究证实了先前的发现，即在每天摄入0.15 ng鱼源CDD / F-TEQs / kg体重的情况下，会诱发肝乙氧基间苯二酚脱乙基酶（EROD）活性。该研究还表明，肝脏维生素A的减少发生在每日暴露水平较高的水平，即鱼来源的CDD / F-TEQs / kg体重为0.16-0.30 ng。卤代脂肪酸是EOCI的主要成分，不能与任何已测结果联系起来。从风险管理的角度来看，该研究为与人体暴露相关的基质中低剂量暴露于有机卤素化合物后的Ah受体介导的反应的作用水平提供了重要的新信息。

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