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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.
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Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.

机译：尼古丁和美卡敏对烟草戒断症状，​​香烟奖励和随意吸烟的急性影响。

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Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were studied in 32 healthy volunteer smokers after overnight abstinence from smoking. Subjects participated in three sessions (3 h each), during which they wore skin patches delivering either 0 mg/24 h, 21 mg/24 h or 42 mg/24 h nicotine. Thirty-two subjects were randomly assigned to two groups receiving oral mecamylamine hydrochloride (10 mg) vs. placebo capsules. Two and one-half hours after drug administration, subjects were allowed to smoke ad lib, rating the cigarettes for rewarding and aversive effects. Transdermal nicotine produced a dose-related reduction in the subjective rewarding qualities of smoking. Nicotine also reduced craving for cigarettes and this effect was attenuated, but not eliminated, by mecamylamine. Mecamylamine blocked the discriminability of high vs. low nicotine puffs of smoke, and increased nicotine intake substantially during the ad lib smoking period. Some of the psychophysiological effects of each drug (elevation in blood pressure from nicotine, sedation and decreased blood pressure from mecamylamine) were offset by the other drug. The results supported the hypothesis that nicotine replacement can alleviate tobacco withdrawal symptoms even in the presence of an antagonist such as mecamylamine. Mecamylamine did not precipitate withdrawal beyond the level associated with overnight cigarette deprivation, suggesting its effects were primarily due to offsetting the action of concurrently administered nicotine as opposed to blocking endogenous cholinergic transmission.
机译：在戒烟过夜后，在32名健康的自愿吸烟者中研究了尼古丁和烟碱类拮抗剂美卡敏的单独和联合作用。受试者参加了三个疗程（每个疗程为3小时），在此期间，他们穿着皮肤贴片输送0毫克/ 24小时，21毫克/ 24小时或42毫克/ 24小时尼古丁。三十二名受试者被随机分为两组，分别接受口服美卡明胺盐酸盐（10毫克）和安慰剂胶囊。给药后两个半小时，受试者被允许随意吸烟，对香烟的奖励和厌恶效果进行评级。经皮尼古丁使吸烟的主观奖励质量与剂量有关。尼古丁还减少了对香烟的渴望，美甲胺降低了这种作用，但并未消除。美加明胺阻止了高烟碱烟量与低烟碱烟量的辨别力，并在自由吸烟期间大幅增加了尼古丁摄入量。每种药物的某些心理生理作用（尼古丁引起的血压升高，美卡敏引起的镇静和血压降低）被另一种药物抵消。该结果支持以下假设：即使存在拮抗剂如美加明，尼古丁替代也可以减轻烟草戒断症状。美加明没有使戒断症状超过与过夜香烟剥夺相关的水平，这表明其作用主要是由于抵消了同时给予尼古丁的作用，而不是阻止内源性胆碱能传播。

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