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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra.
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Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra.

机译：大鼠黑质注入卡巴胆碱和乙酰胆碱酯酶的行为效果比较。

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摘要

It has been postulated for many years that acetylcholinesterase (AChE) may play a nonclassical role in the substantia nigra, unrelated to its ability to hydrolyse acetylcholine. In this study the behavioural effects of unilateral infusion of AChE and a cholinergic agonist, carbachol, were compared. Carbachol induced ipsiversive circling over a very short time scale (minutes), whereas AChE induced contraversive circling, but over a longer time course-10 days. Both agents showed selectivity of response within the substantia nigra: acetylcholinesterase was only effective when infused into the most rostral region of the substantia nigra and its effects were limited to the pars compacta. In contrast, carbachol had effects in both the pars compacta and reticulata, with a graded sensitivity to carbachol in the rostral/caudal plane; infusions into rostral regions induced high rates of circling compared to more caudal areas, suggesting that the cholinergic input to the substantia nigra is not homogenous, but greater in rostral regions. This disparity between the effects of carbachol and AChE would, therefore, suggest that AChE is not exerting its long-term behavioural actions via a cholinergic mechanism, both in terms of time course of the response and the areas within the substantia nigra sensitive to these agents.
机译：多年以来一直假定乙酰胆碱酯酶（AChE）可能在黑质中起非经典作用，与其水解乙酰胆碱的能力无关。在这项研究中，比较了单方输注AChE和胆碱能激动剂卡巴胆碱的行为效应。卡巴胆碱在很短的时间尺度（分钟）内引起同性盘旋，而乙酰胆碱酯酶则在较长的过程中（10天）诱导对立盘旋。两种药物都显示出对黑质内反应的选择性：乙酰胆碱酯酶仅在注入黑质的最延性区域时才有效，并且其作用仅限于致密粉。相比之下，卡巴胆碱在致密粉和网纹中均具有影响，在鼻/尾平面对卡巴胆碱具有分级敏感性。相比于更多的尾部区域，向延髓区域的输注引起较高的循环率，这表明向黑质的胆碱能输入不是均匀的，但是在延髓区域更大。因此，卡巴胆碱和AChE的作用之间的这种差异表明，AChE不会通过胆碱能机制发挥其长期的行为作用，无论是反应的时间过程还是对这些药物敏感的黑质内区域。

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