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Dissociating the nicotine and airway sensory effects of smoking.

机译:消除吸烟对尼古丁和气道的感觉影响。

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摘要

This study examined the subjective and cardiovascular effects of two of the components of cigarette smoking when given separately: nicotine and airway sensations. Using a within-subjects design, six healthy volunteer smokers, age 18-45 years, who smoked at least 20 cigarettes per day were given six conditions in a randomized, counterbalanced order. The effects of IV nicotine, IV saline, and denicotinized cigarettes were compared to a standard 1-mg cigarette. The standard cigarette produced more of a calming effect and more irritability reduction than either the nicotine or airway sensations alone. The denicotinized cigarette was similar to the standard cigarette condition, except the cigarette condition was associated with higher feelings of "exhilaration." Many of the positive subjective effects from a denicotinized cigarette were comparable to that of a standard cigarette. These data support the hypothesis that replacement of the sensory cues of smoking with "airway sensory replacement" may be usefulfor smoking cessation.
机译:这项研究检查了分开服用两种成分的吸烟对主观和心血管的影响:尼古丁和呼吸道感觉。采用受试者内部设计,对六名年龄在18-45岁之间,每天吸烟至少20支的健康自愿吸烟者,按照随机,平衡的顺序给予六种条件。将IV尼古丁,IV盐水和去甲烟的卷烟与标准的1 mg卷烟的效果进行了比较。与单独的尼古丁或呼吸道感觉相比,标准卷烟具有更多的镇静效果和更多的烦躁性降低。除烟味与标准烟味相似,不同之处在于烟味与较高的“兴奋感”相关。脱硝烟的许多积极主观效果可与标准烟媲美。这些数据支持这样的假设,即用“气道感觉替代”替代吸烟的感觉提示可能对戒烟有用。

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