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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Selective effects of 8-OH-DPAT on social competition in the rat.
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Selective effects of 8-OH-DPAT on social competition in the rat.

机译：8-OH-DPAT对大鼠社会竞争的选择性作用。

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Previous research has demonstrated that dominant-subordinate relationships measured in small groups of rats competing for access to palatable food or fluids can be disrupted by both anxiolytic and anxiogenic drugs, and it has been proposed as a possible animal model of anxiety. The present study investigated the effects of the selective 5-HT1A agonist 8-OH-DPAT on the rank order of triads of rats measured in terms of access to sweetened milk. The effect of 8-OH-DPAT on locomotor activity and intake of sweetened milk was also determined. 8-OH-DPAT (25 and 37.5 micrograms/kg) significantly increased the subordinate animals position in the social hierarchy without effect on the individual intakes of sweetened milk or locomotor activity. The same doses administered to dominant animals had no effect on any of the parameters measured. The 8-OH-DPAT-induced increase in social competition in subordinate rats was dissociable from effects on feeding behavior and locomotor activity. The results from this study provide further evidence that social competition in groups of rats may represent a model that can be used to detect drugs acting via receptor mechanisms believed to be implicated in anxiety.
机译：先前的研究表明，抗争药和抗焦虑药均可破坏在争夺可口食物或水的竞争的小群大鼠中测得的主从关系，并且已提出将其作为可能的焦虑症动物模型。本研究调查了选择性5-HT1A激动剂8-OH-DPAT对三合一大鼠的三级排序的影响（以获取甜牛奶的方式衡量）。还确定了8-OH-DPAT对运动活性和甜奶摄入量的影响。 8-OH-DPAT（25和37.5微克/千克）显着提高了下等动物在社会等级中的位置，而不会影响个体摄入的甜牛奶或运动能力。对优势动物施用相同剂量对所测参数均无影响。 8-OH-DPAT诱导的下级大鼠社会竞争的增加与对进食行为和运动活动的影响是分离的。这项研究的结果提供了进一步的证据，表明大鼠组中的社会竞争可能代表了一种模型，该模型可用于检测通过被认为与焦虑有关的受体机制起作用的药物。

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