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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal.
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Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal.

机译：耐受尼古丁在高迷宫中的作用，并在戒断期间增加焦虑感。

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摘要

In the elevated plus-maze test of anxiety, nicotine (0.1 mg/kg sc; 30 min after injection) had a significant anxiogenic effect, shown by specific decreases in the percentage of time spent on the open arms and in the percentage of open-arm entries. Tolerance developed to this anxiogenic effect after 7 days of nicotine treatment (0.1 mg/kg/day). Five minutes after an acute injection, nicotine (0.1 mg/kg) was ineffective, but after 7 days of treatment a significant anxiolytic effect, shown by specific increases in the percentage of time spent on the open arms and in the percentage of open-arm entries, emerged. After 14 days of nicotine treatment, tolerance developed to this anxiolytic effect. There was a complete dissociation between the effects of nicotine on the measures of anxiety, and on the locomotor activity as measured by closed-arm entries. No changes in closed-arm entries were found after acute administration of nicotine, but rats tested 30 min after their 7th injection made significantly fewer, and those tested 5 min after their 14th injection made significantly more, entries than their respective controls. Rats that were tested after 24 h withdrawal from six daily nicotine injections showed a significant anxiogenic effect. A low dose of nicotine (5 ng) injected into the dorsal hippocampus was without effect in vehicle pretreated rats, but it was able to reverse the anxiogenic effect found after 24 h of withdrawal from 6 days of nicotine treatment.
机译：在焦虑症的高迷迷宫测试中，尼古丁（0.1 mg / kg sc;注射后30分钟）具有显着的抗焦虑作用，具体表现为张开双臂的时间百分比和张开双臂的百分比显着减少。手臂条目。尼古丁治疗7天（0.1 mg / kg /天）后，对这种抗焦虑作用产生了耐受性。急性注射后五分钟，尼古丁（0.1 mg / kg）无效，但治疗7天后有显着的抗焦虑作用，具体表现为张开双臂的时间百分比和张开双臂的百分比明显增加条目，出现了。尼古丁治疗14天后，对这种抗焦虑作用产生了耐受性。尼古丁对焦虑程度的影响与闭环运动对运动能力的影响之间存在完全的分离。急性给予尼古丁后未发现闭合臂进入的变化，但第7次注射后30分钟测试的大鼠明显减少，而第14次注射后5分钟测试的大鼠明显增加。从每天六次尼古丁注射中撤出24小时后测试的大鼠表现出显着的抗焦虑作用。在经媒介物预处理的大鼠中，向海马背侧注射低剂量尼古丁（5 ng）无效，但能够逆转从尼古丁治疗第6天停药24小时后发现的焦虑作用。

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