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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of D-amphetamine on responding for candy and fruit drink using a fixed ratio and a progressive ratio schedule of reinforcer delivery.
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The effects of D-amphetamine on responding for candy and fruit drink using a fixed ratio and a progressive ratio schedule of reinforcer delivery.

机译：D-苯丙胺对糖果和果汁饮料响应的作用，使用固定比例和渐进比例的增强剂输送时间表。

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The first purpose of this study was to compare the effects of D-amphetamine (AMPH) on operant responding reinforced under fixed ratio (FR) or progressive ratio (PR) schedules of reinforcement, testing the hypothesis that responding reinforced under a PR operant schedule would be disrupted by lower doses of AMPH than responding reinforced under a FR operant schedule. The second purpose of this study was to test the generalizability of the first hypothesis by comparing the effects of AMPH on responding reinforced by two different reinforcers under both FR and PR operant schedules. Rhesus monkeys had five to six candy and five to six fruit drink sessions per day, and could receive two reinforcers per session. Responding was initially reinforced under a PR procedure, such that the ratio size increased with each subsequent session. The parameters of the PR schedule were individually selected so that monkeys consumed a similar number of candy and fruit-drink reinforcers each day. The effects of oral AMPH (0.5, 0.75, 1.0 mg/kg) on responding were assessed. Responding was then stabilized using a FR schedule with parameters individually selected so that monkeys consumed a similar number of candy and fruit-drink reinforcers each day, and the effects of oral AMPH were again assessed. The PR breakpoint was significantly greater for candy than fruit-drink. AMPH produced dose-related decreases in both candy and fruit-drink intake, but each AMPH dose decreased the number of fruit-drink deliveries to a greater extent than the number of candy deliveries. The results failed to support the hypothesis that responding under PR schedules of reinforcement would be disrupted by lower doses of AMPH.
机译：这项研究的第一个目的是比较D-苯丙胺（AMPH）对固定比例（FR）或渐进比例（PR）强化计划下的操作员响应的影响，检验在PR作业时间表下进行响应的假设的假设。相比于在FR操作方案下加强反应，AMPH的剂量更低。这项研究的第二个目的是通过比较AMP和FR操作计划下两种不同增强剂对AMPH的响应效果来检验第一个假设的一般性。恒河猴每天要吃五到六个糖果和五到六个水果饮料，并且每个会话可以接受两个补强剂。最初，在PR程序中加强了响应，因此比率大小随后续会话的增加而增加。单独选择PR时间表的参数，以便猴子每天消耗相似数量的糖果和水果饮料增强剂。评估了口服AMPH（0.5、0.75、1.0 mg / kg）对缓解的影响。然后使用FR时间表稳定响应，并分别选择参数，以使猴子每天消耗相似数量的糖果和水果饮料增强剂，并再次评估口服AMPH的效果。糖果的PR断点明显大于果汁饮料。 AMPH导致糖果和水果饮料的摄入量与剂量相关的减少，但每次AMPH剂量所减少的水果饮料的输送量要比糖果的输送量更大。结果未能支持这样的假说，即在PR强化计划下的反应将被较低剂量的AMPH干扰。

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