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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A study of the nicotinic agonist SIB-1553A on locomotion and attention as measured by the five-choice serial reaction time task.
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A study of the nicotinic agonist SIB-1553A on locomotion and attention as measured by the five-choice serial reaction time task.

机译：通过五选择序列反应时间任务测量的烟碱激动剂SIB-1553A对运动和注意力的研究。

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SIB-1553A is a novel ligand with reputed agonist selectivity at nicotinic receptors containing the beta(4) subunit. As such, it represents an interesting pharmacological tool with which to probe the function of nicotine receptor subtypes. In the present studies, we compared SIB-1553A with nicotine in its ability to stimulate locomotion and to enhance attention in rats as assessed using the five-choice serial reaction time task (5-CSRTT). In nicotine-naive rats, SIB-1553A (10-40 mg/kg) induced a comparable increase in locomotion to nicotine (0.4 mg/kg), whereas in nicotine-sensitised rats, an enhanced locomotor response was seen to nicotine (0.4 mg/kg) but not to SIB-1553A (10-80 mg/kg). Similarly, chronic treatment with either SIB-1553A or nicotine did not lead to a cross-sensitised locomotor response. Unlike nicotine, SIB-1553A-induced locomotion was insensitive to antagonism by either mecamylamine (1 mg/kg) or DH beta E (3 mg/kg), suggesting a non-nicotinic mechanism. In young and aged rats, nicotine (0.4 mg/kg) enhanced attention as demonstrated by an increase in response accuracy and speed. SIB-1553A (3-10 mg/kg) did not mimic any of these changes and at the highest dose tended to disrupt performance. These results lend further support to the involvement of a high affinity site, possibly alpha(4)beta(2), in the locomotor and attentional-enhancing properties of nicotine.
机译：SIB-1553A是一种新型配体，在含有β（4）亚基的烟碱受体上具有公认的激动剂选择性。因此，它代表了一种有趣的药理学工具，可用来探测尼古丁受体亚型的功能。在本研究中，我们将SIB-1553A与尼古丁的刺激运动能力和增强大鼠注意力的能力进行了比较，如使用五项选择连续反应时间任务（5-CSRTT）进行评估。在未使用尼古丁的大鼠中，SIB-1553A（10-40 mg / kg）诱导的运动与尼古丁（0.4 mg / kg）相当，而在对尼古丁敏感的大鼠中，观察到尼古丁（0.4 mg）的运动反应增强/ kg），而不是SIB-1553A（10-80 mg / kg）。同样，用SIB-1553A或尼古丁进行长期治疗也不会导致交叉致敏的运动反应。与尼古丁不同，SIB-1553A诱导的运动对美卡敏（1 mg / kg）或DHβE（3 mg / kg）的拮抗作用不敏感，表明是非烟碱性机制。在年轻和老年大鼠中，尼古丁（0.4 mg / kg）增强了注意力，这通过提高响应准确度和速度来证明。 SIB-1553A（3-10 mg / kg）没有模拟任何这些变化，并且在最高剂量下倾向于破坏性能。这些结果进一步支持了高亲和力位点（可能是alpha（4）beta（2））参与尼古丁的运动和注意力增强特性。

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