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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome.
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Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome.

机译：针对尼古丁的被动免疫可防止尼古丁缓解尼古丁戒断综合征。

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Passive immunization against nicotine interferes with its locomotor and pressor effects. The current study determined whether immunization could prevent another nicotine action: the reversal of nicotine abstinence syndrome. IgG containing 4.4-5.6% nicotine-specific antibody was isolated from rabbits immunized with 3'-amino-methyl-nicotine conjugated to a carrier protein. Twenty rats were rendered dependent by 7 days of subcutaneous infusion of 3.15 mg/kg/day nicotine (expressed as the base). Upon termination of nicotine infusion, each rat was injected intraperitoneally with 150 mg of IgG from normal serum (n=13) or from nicotine antiserum (n=7). Twenty-two and one-half hours later, all rats were observed over 15 min for baseline nicotine abstinence signs. Two and one-half hours after baseline observations, seven of the 13 rats pretreated with control IgG and all seven rats pretreated with nicotine-specific IgG were then challenged by 0.12 mg/kg (sc) nicotine. The remaining six rats pretreated with control IgG were challenged with saline alone. All rats were then observed again for abstinence signs. Nicotine injection caused significantly less reduction of abstinence signs in the immunized rats. The nicotine effect in immunized rats was comparable to the saline effect in nonimmunized rats. Immunization also significantly reduced free serum nicotine concentration and nicotine distribution to the brain. These results raise the possibility that immunization might prevent nicotine consumption from relieving the discomforts of smoking cessation.
机译：尼古丁的被动免疫会干扰其运动和升压作用。目前的研究确定了免疫接种是否可以阻止尼古丁的另一项作用：逆转尼古丁戒断综合征。从用与载体蛋白缀合的3'-氨基-甲基-烟碱免疫的兔中分离出含有4.4-5.6％烟碱特异性抗体的IgG。皮下输注尼古丁3.15 mg / kg /天7天（表示为基础）使20只大鼠成为依赖。尼古丁输注结束后，每只大鼠腹膜内注射150 mg正常血清（n = 13）或尼古丁抗血清（n = 7）的IgG。 22和半小时后，在15分钟内观察所有大鼠的尼古丁戒断症状。基线观察后两个半小时，用对照IgG预处理的13只大鼠中的7只和用尼古丁特异性IgG预处理的所有7只大鼠随后接受0.12 mg / kg（sc）尼古丁的攻击。用对照IgG预处理的其余六只大鼠仅用盐水攻击。然后再次观察所有大鼠的禁欲迹象。尼古丁注射引起免疫大鼠禁欲症状的减少明显更少。免疫大鼠的尼古丁效应与未免疫大鼠的生理盐水相当。免疫还显着降低了血清游离尼古丁浓度和尼古丁向大脑的分布。这些结果增加了免疫可能阻止尼古丁消耗减轻戒烟不适的可能性。

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