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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.
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Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.

机译：丘脑的丘脑5-HT（1A）和5-HT（1B）受体调节的大鼠RU 24969诱导的行为模式。

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摘要

The effects of systemic administration of the serotonin (5-HT)(1A/1B) agonist 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)1H-indole (RU 24969) on locomotor and investigatory behavior in rats have been well characterized using the behavioral pattern monitor (BPM). To elucidate the neural circuitry underlying this behavioral profile, intracerebral dose--response studies were conducted at two sites with high densities of 5-HT(1B) receptors, the subthalamic nucleus (STN) and substantia nigra. Infusion of RU 24969 into the STN produced systemic RU 24969-like changes in locomotor activity and patterns but an uncharacteristic increase in investigatory holepokes. Intra-STN administration of the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) produced RU 24969-like changes in locomotor patterns only, while the 5-HT(1B) receptor agonist 3(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one dihydrochloride (CP-93,129) increased locomotor activity, produced no change in locomotor patterns and nonsignificantly increased holepokes. Intranigral infusion of RU 24969 produced systemic and intra-STN RU 24969-like increases in locomotor activity. Intranigral RU 24969, however, failed to produce any changes in locomotor patterns or investigatory holepokes. Intranigral infusions of CP-93,129 or 8-OH-DPAT had no effects on locomotor activity, locomotor patterns or investigatory holepokes. These results provide evidence for multiple-site mediation of the locomotor-activating effects of RU 24969 and for a dissociation of the neural substrates underlying locomotor and investigatory components of the RU 24969-induced behavioral profile.
机译：全身给药5-羟色胺（5-HT）（1A / 1B）激动剂5-甲氧基-3-（1,2,3,6-四氢吡啶-4-基）1H-吲哚（RU 24969）对运动和使用行为模式监控器（BPM）可以很好地表征大鼠的调查行为。为了阐明这种行为模式背后的神经回路，在具有高密度5-HT（1B）受体的两个部位（丘脑下核（STN）和黑质）进行了脑内剂量反应研究。向STN中注入RU 24969可产生运动性活动和模式的系统性RU 24969样变化，但调查性空穴传递异常增加。 STN内选择性5-HT（1A）受体激动剂8-羟基-2-（di-N-丙基氨基）四氢化萘（8-OH-DPAT）的给药仅在运动模式上产生RU 24969样变化，而5 -HT（1B）受体激动剂3（1,2,5,6-四氢吡啶-4-基）吡咯并[3,2-b]吡啶-5-一二盐酸盐（CP-93,129）增加了运动活性，未产生变化运动模式和显着增加的洞戳。鼻内输注RU 24969可产生全身性和STN内RU 24969样运动能力的增加。但是，Intranigral RU 24969未能在运动模式或调查性戳破中产生任何变化。鼻内输注CP-93,129或8-OH-DPAT对运动能力，运动模式或调查性打孔没有影响。这些结果为RU 24969的运动激活作用的多部位介导以及RU 24969诱导的行为特征的运动和研究成分下的神经底物的解离提供了证据。

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