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5-Hydroxytryptamine and interval timing behaviour.

机译：5-羟色胺和间隔时间行为。

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Interval timing behaviour is revealed by prospective, immediate and retrospective timing schedules. Prospective timing tasks are used to study intertemporal choice (choice between outcomes occurring after different delays), immediate timing tasks to study temporal differentiation (temporal regulation of the animal's behaviour) and retrospective timing tasks to study temporal discrimination (discrimination between the durations of external events). Central 5-hydroxytryptamine (5-HT) depletion promotes preference for small early reinforcers over large delayed reinforcers, possibly by facilitating the time-dependent degradation of reinforcer value. Central 5-HT depletion retards the learning of temporal differentiation, and increases the variability of timing in some immediate timing tasks; however, it does not impede (in some cases it facilitates) the acquisition of temporal discrimination. Attempts to ascribe all the effects of 5-HT depletion on timing to a single behavioural process have been unsuccessful, although disinhibition of switching between operant responses may account for some of the findings. Acute treatment with drugs affecting 5-HTergic mechanisms alters timing behaviour in qualitatively different ways in different timing schedules, casting doubt on the idea that the effects of these drugs are mediated by interaction with a unitary timing process. The receptors that mediate 5-HT's putative involvement in interval timing behaviour remain to be identified.
机译：间隔计时行为通过预期的，立即的和回顾性的计时时间表来揭示。预期的计时任务用于研究时间间的选择（在不同的延迟后发生的结果之间的选择），即时的计时任务用于研究时间的差异（动物行为的时间调节），回顾性的计时任务用于研究时间的歧视（外部事件持续时间之间的区别） ）。中央5-羟色胺（5-HT）耗竭可能会促进增强剂的价值随时间而降低，从而使大型早期增强剂优先于小型早期增强剂。中枢5-HT耗竭阻碍了时间差异的学习，并增加了一些即时计时任务中计时的可变性。但是，它不会妨碍（在某些情况下会促进）时间歧视的获得。尝试将5-HT耗竭的影响归因于单个行为过程的时机并未成功，尽管禁止在操作者应答之间切换可能是一些发现的原因。用影响5-HT能机制的药物进行的急性治疗会在不同的时间安排中以定性的不同方式改变时间行为，这使人们怀疑这些药物的作用是通过与单一时间过程的相互作用来介导的。介导5-HT推测参与间隔计时行为的受体仍有待确定。

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