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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Iron deficiency in rats decreases acquisition of and suppresses responding for cocaine.
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Iron deficiency in rats decreases acquisition of and suppresses responding for cocaine.

机译：大鼠铁缺乏会减少对可卡因的吸收并抑制其响应。

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Iron deficiency impairs nigrostriatal and mesolimbic dopamine systems by causing decreased densities of D(1) and D(2) receptors and the dopamine transporter in the terminal fields, caudate-putamen and nucleus accumbens. Iron deficiency also causes deficits in dopamine-related pharmacological indices, e.g., deficits in locomotor stimulation by cocaine and locomotor inhibition by raclopride. Based on this knowledge, we hypothesized that iron deficiency would have a major impact on cocaine self-administration. Male Sprague-Dawley rats were fed an iron-deficient diet starting at weaning (Day 21) and continuing throughout the experiment. At 57-58 days of age, all animals had catheters implanted surgically into the jugular vein. Approximately 2 weeks later, all animals were trained to lick an empty spout for intravenous cocaine, delivered by infusion pump at 0.33 mg/kg. During the course of training, all animals acquired intravenous cocaine self-administration, however, the course of acquisition was significantly slower for the iron-deficient animals. When tested for responding on a progressive ratio (PR) schedule, the control animals maintained a constant number of infusions, whereas the responding of the iron-deficient animals fell off sharply. When the dose of cocaine was decreased, control, but not iron-deficient adjusted the amount administered by increasing the number of infusions. Finally, the failure to respond by the iron-deficient animals was not simply due to a failure to lick (i.e., a motor impairment), because both the iron-deficient and the control animals emitted approximately 1000 licks/20 min session when given free access to a palatable 0.1 M sucrose solution. Taken together, the data show that severe iron deficiency early in life can diminish the capacity of cocaine, but not sucrose to reinforce behavior. The question raised by this research thus, is whether iron deficiency alters hedonic-like responses only to dopamine-related behaviors and the degree to which willingness to "work" contributes to the effect.
机译：缺铁会导致D（1）和D（2）受体以及末端区域，尾状-丘脑和伏隔核中的多巴胺转运蛋白的密度降低，从而损害黑质纹状体和中脑边缘的多巴胺系统。铁缺乏还引起多巴胺相关药理学指标的缺陷，例如可卡因运动刺激的缺陷和雷氯必利运动抑制的缺陷。基于此知识，我们假设铁缺乏会对可卡因的自我管理产生重大影响。从断奶（第21天）开始为雄性Sprague-Dawley大鼠喂食铁缺乏饮食，并在整个实验中继续进行。在57-58日龄时，所有动物均已通过外科手术将导管植入颈静脉。大约2周后，训练所有动物舔一个空的静脉注射可卡因的喷口，静脉注射可卡因，剂量为0.33 mg / kg。在训练过程中，所有动物都获得了静脉注射可卡因自我给药，但是，对于铁缺乏的动物，获得过程明显较慢。当按渐进比率（PR）时间表测试反应性时，对照动物保持恒定的输注次数，而铁缺乏动物的反应性急剧下降。当可卡因的剂量减少时，对照（而非铁缺乏）可通过增加输注次数来调整给药量。最后，缺铁动物的反应失败不仅仅是由于舔失败（即运动障碍），因为缺铁动物和对照动物在免费给予时大约每20分钟发出1000舔s获得可口的0.1 M蔗糖溶液。综上所述，数据表明，生命早期严重的铁缺乏会降低可卡因的能力，但不能增强蔗糖的行为能力。因此，这项研究提出的问题是，铁缺乏症是否仅改变对多巴胺相关行为的享乐主义反应，以及“工作”的意愿在多大程度上影响了这种效应。

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