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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM.
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The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM.

机译：氟西汀和西酞普兰急性和亚慢性治疗对DOM刺激控制的影响。

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Previous reports from our laboratory have provided evidence that acute, i.e., concurrent, treatment with selective serotonin reuptake inhibitors (SSRIs) augments the stimulus effects of indoleamine and phenethylamine hallucinogens in the rat. In the present investigation, the acute effects of fluoxetine and citalopram on stimulus control induced by (-)-2,5-dimethoxy-4-methylamphetamine (DOM) were compared with those following subchronic, i.e., 10-day treatment with the SSRIs. Stimulus control was established using DOM (0.56 mg/kg; 75-min pretreatment time) in a group of 11 rats. A two-lever, fixed ratio 10, positively reinforced task with saline controls was employed. The effects of a range of doses of DOM when given alone were compared with those following both acute and subchronic pretreatment with fluoxetine and citalopram in combination with DOM. It was found that acute administration of fluoxetine and citalopram potentiated the stimulus effects of DOM. Furthermore, it was observed that the degree of potentiation was not diminished by treatment with either fluoxetine or citalopram for a period of 10 days. It is concluded that whatever adaptive changes may take place in response to a 10-day period of treatment with either citalopram or fluoxetine, these adaptations are independent of the mechanisms responsible for the potentiation of the stimulus effects of DOM by the SSRIs.
机译：我们实验室以前的报道提供了证据，即用选择性5-羟色胺再摄取抑制剂（SSRI）进行的急性（即同时治疗）可增强吲哚胺和苯乙胺的致幻剂对大鼠的刺激作用。在本研究中，将氟西汀和西酞普兰对（-）-2,5-二甲氧基-4-甲基苯丙胺（DOM）诱导的刺激控制的急性作用与亚慢性（即用SSRIs治疗10天）进行了比较。在11只大鼠的一组中，使用DOM（0.56 mg / kg; 75分钟的预处理时间）建立刺激控制。采用两杆固定比例10的正强化任务，并带有盐水对照。将单独给予一定剂量的DOM的效果与氟西汀和西酞普兰联合DOM进行的急性和亚慢性预处理后的效果进行了比较。已经发现，氟西汀和西酞普兰的急性给药增强了DOM的刺激作用。此外，观察到用氟西汀或西酞普兰治疗10天并未增强电位。结论是，无论用西酞普兰或氟西汀治疗10天后可能发生何种适应性变化，这些适应性变化均与SSRI增强DOM刺激作用的机制无关。

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