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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Central stimulants as discriminative stimuli. Asymmetric generalization between (-)ephedrine and S(+)methamphetamine.
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Central stimulants as discriminative stimuli. Asymmetric generalization between (-)ephedrine and S(+)methamphetamine.

机译：中央刺激物作为歧视性刺激物。 （-）麻黄碱和S（+）甲基苯丙胺之间的不对称泛化。

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Central stimulants readily serve as training stimuli in drug discrimination studies and typically substitute for one another in tests of stimulus generalization regardless of which is used as training drug. We have previously found that, although substitution occurs between (+)amphetamine and (-)ephedrine, substitution did not occur upon administration of S(+)methamphetamine to (-)ephedrine-trained animals. In the present investigation, rats were trained to discriminate S(+)methamphetamine (1 mg/kg) from saline vehicle and tests of stimulus generalization were performed with several stimulants, including (-)ephedrine. The S(+)methamphetamine stimulus (ED(50)=0.06 mg/kg) generalized to R(-)methamphetamine (ED(50)=1.61 mg/kg), S(+)amphetamine (ED(50)=0.28 mg/kg), S(-)methcathinone (ED(50)=0.21 mg/kg), methylphenidate (ED(50)=0.28 mg/kg), cocaine (ED(50)=3.68 mg/kg) and (-)ephedrine (ED(50)=13.1 mg/kg). Hence, stimulus generalization between S(+)methamphetamine and (-)ephedrine is apparently asymmetrical.In a companion study, R(-)methamphetamine was administered to rats trained to discriminate (-)ephedrine (4 mg/kg); substitution occurred and R(-)methamphetamine (ED(50)=0.92 mg/kg) was found to be nearly equipotent with (-)ephedrine (ED(50)=0.8 mg/kg). Although the exact basis for the observed results are unclear, they are discussed in terms of the different effects of (-)ephedrine and the methamphetamine optical isomers on neurotransmitter release and reuptake.
机译：中央刺激物很容易在毒品歧视研究中用作训练刺激物，并且通常在刺激性泛化测试中相互替代，而不论使用哪种作为训练药物。先前我们已经发现，尽管取代发生在（+）苯丙胺和（-）麻黄碱之间，但是在将S（+）甲基苯丙胺施用于（-）麻黄碱训练的动物后，取代没有发生。在本研究中，训练大鼠从盐水媒介物中区分S（+）甲基苯丙胺（1 mg / kg），并使用几种兴奋剂（包括（-）麻黄碱）进行刺激泛化试验。 S（+）甲基苯丙胺刺激（ED（50）= 0.06 mg / kg）泛化为R（-）甲基苯丙胺（ED（50）= 1.61 mg / kg），S（+）苯丙胺（ED（50）= 0.28 mg / kg），S（-）甲卡西酮（ED（50）= 0.21 mg / kg），哌醋甲酯（ED（50）= 0.28 mg / kg），可卡因（ED（50）= 3.68 mg / kg）和（-）麻黄碱（ED（50）= 13.1 mg / kg）。因此，S（+）甲基苯丙胺与（-）麻黄碱之间的刺激作用显然是不对称的。发生了取代，发现R（-）甲基苯丙胺（ED（50）= 0.92 mg / kg）与（-）麻黄碱（ED（50）= 0.8 mg / kg）几乎等效。尽管尚不清楚观察结果的确切依据，但将根据（-）麻黄碱和甲基苯丙胺旋光异构体对神经递质释放和再摄取的不同影响进行讨论。

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