• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prepulse inhibition in rats with temporary inhibition/inactivation of ventral or dorsal hippocampus.
【24h】

Prepulse inhibition in rats with temporary inhibition/inactivation of ventral or dorsal hippocampus.

机译：大鼠的前脉冲抑制，暂时抑制/灭活腹侧或背侧海马。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prepulse inhibition (PPI) of the acoustic startle response is a measure of sensorimotor gating and is decreased in neuropsychiatric diseases, including schizophrenia. Hippocampal involvement in PPI has been the subject of several studies, in particular, as aberrant hippocampal activity has been associated with schizophrenia. In rats, chemical stimulation of the ventral hippocampus reduced PPI, while normal PPI was found following hippocampal lesions, suggesting that ventral hippocampal overactivity is detrimental for PPI, but that normal hippocampal activity does not contribute substantially to PPI. In the present study, we investigated the importance of hippocampal activity for PPI by examining PPI in Wistar rats with temporarily decreased hippocampal activity, aiming to avoid compensatory processes that may occur with permanent lesions. Bilateral ventral or dorsal hippocampal infusions of the gamma-aminobutyric acid A (GABA(A)) receptor agonist muscimol (1 microg/side) or the sodium-channel blocker tetrodotoxin (TTX, 10 ng/side) reduced PPI. This reduction is probably neuroleptic-resistant since haloperidol and clozapine did not antagonize the muscimol-induced decreases in PPI. PPI reduction by muscimol inhibition or TTX inactivation of the dorsal or ventral hippocampus indicates that hippocampal activity contributes to sensorimotor gating, suggesting intact PPI after permanent hippocampal lesions to reflect compensatory processes. The data are discussed with respect to hippocampal dysfunction in schizophrenia.
机译：听觉惊吓反应的前脉冲抑制（PPI）是感觉运动门控的一种测量方法，在包括精神分裂症在内的神经精神疾病中有所降低。特别是由于海马活动异常与精神分裂症有关，海马参与PPI成为多项研究的主题。在大鼠中，腹侧海马的化学刺激降低了PPI，而在海马损伤后发现正常的PPI，表明腹侧海马过度活动对PPI有害，但是正常的海马活动对PPI没有实质性贡献。在本研究中，我们通过检查暂时性降低海马活动的Wistar大鼠中的PPI，调查了海马活动对PPI的重要性，旨在避免永久性病变可能发生的代偿过程。双边腹侧或背侧海马输注γ-氨基丁酸A（GABA（A））受体激动剂麝香酚（1 microg /侧）或钠通道阻滞剂河豚毒素（TTX，10 ng /侧）可降低PPI。由于氟哌啶醇和氯氮平没有拮抗由muscimol引起的PPI下降，因此这种降低可能是抗精神病药耐药的。通过对背侧或腹侧海马进行muscimol抑制或TTX失活来降低PPI，表明海马活动有助于感觉运动门控，表明永久性海马损伤后完整的PPI反映了补偿过程。讨论了有关精神分裂症海马功能障碍的数据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号