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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Repeated maternal separation does not alter sucrose-reinforced and open-field behaviors.
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Repeated maternal separation does not alter sucrose-reinforced and open-field behaviors.

机译：重复的母体分离不会改变蔗糖强化和旷场行为。

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Repeated separation of rat pups from their mothers has been reported to increase behavioral fearfulness and hypothalamic-pituitary-adrenal (HPA) response to stress. Recently, it was suggested that it might also alter behavioral responses to natural and drug rewards. Here, we studied whether maternal separation (MS) would alter behavioral responses to a sucrose reward. We also tested whether MS would alter behavioral responses in an open-field test using a novel method of analysis [Software for the Exploration of Exploration (SEE)]. Long-Evans rat pups were exposed to either 180 min of MS, 15 min of separation [early handling (EH)] or left undisturbed [nonhandled (NH)] from postnatal day (PND) 3 to 14. The adult male offspring were tested for sucrose solution preference using a two-bottle free-choice test, operant response for sucrose under fixed ratio and progressive ratio (PR) schedules of reinforcement and response to a novel environment (open-field test). MS had no effect on sucrose preference or operant responding for sucrose reward. In the open-field test, NH rats showed a brief decrease in locomotor response, but MS rats did not differ from the NH and EH groups in the other behavioral measures. Thus, under the conditions of the present study, MS did not appear to alter reward-related processes and also had a minimal effect on open-field behavior.
机译：据报道，大鼠幼崽与母亲的反复分离会增加行为上的恐惧感和下丘脑-垂体-肾上腺（HPA）对压力的反应。最近，有人建议它也可能改变对自然和药物奖励的行为反应。在这里，我们研究了母体分离（MS）是否会改变对蔗糖奖励的行为反应。我们还使用一种新颖的分析方法[探索勘探软件（SEE）]测试了MS是否会在野外测试中改变行为响应。从出生后第3天到14天，将Long-Evans大鼠幼崽暴露于MS的180分钟，分离的15分钟[早期处理（EH）]或不受干扰的[未处理（NH）]。对成年雄性后代进行了测试对于使用两瓶自由选择测试的蔗糖溶液偏爱，在固定比例和渐进比例（PR）强化方案下对蔗糖的操作响应以及对新环境的响应（开放视野测试）。 MS对蔗糖偏爱或操作者对蔗糖奖励的反应没有影响。在野外试验中，NH大鼠表现出运动反应的短暂降低，但MS大鼠在其他行为指标上与NH和EH组没有区别。因此，在本研究的条件下，MS似乎没有改变与奖励相关的过程，并且对露天行为的影响也很小。

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