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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Handling, genetic and housing effects on the mouse stress system, dopamine function, and behavior.
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Handling, genetic and housing effects on the mouse stress system, dopamine function, and behavior.

机译：处理，遗传和住房对小鼠应激系统，多巴胺功能和行为的影响。

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This research was designed to examine how early stimulation (i.e., handling), subsequent housing conditions and genetic factors interact to produce adult differences in stress regulation. High-aggressive (NC900) and low-aggressive (NC100) mice were handled for 3 weeks potspartum and were subsequently isolated or grouped until observed as adults in an open field or a dyadic test. In NC100, handling abolished the temporal variations seen in open-field activity among the nonhandled subjects and reduced corticosterone (CORT) activation. In NC900, these two measures were unaffected by handling. Only among handled NC100 did subsequent group rearing further reduce CORT activation. By contrast, handling caused an up-regulation of D1 dopamine receptors in both lines, and, in NC100, this effect was increased by group rearing. In a dyadic encounter with another male mouse, subjects of both lines showed handling effects. NC100 froze less rapidly and NC900 attacked more rapidly. This multifactorial design showed that the systemic effects of handling are modulated by genetic background, and that measures of these effects are affected by experience beyond infancy. Our findings also showed that the effects of handling vary when assessed across different physiological systems and across social and nonsocial testing conditions.
机译：这项研究旨在检查早期刺激（即处理），随后的住房条件和遗传因素如何相互作用，从而在压力调节方面产生成年差异。高侵略性（NC900）和低侵略性（NC100）小鼠在产褥期处理3周，随后进行隔离或分组，直到在野外或二进位试验中观察为成年小鼠为止。在NC100中，处理消除了未处理受试者在野外活动中看到的时间变化，并降低了皮质酮（CORT）激活。在NC900中，这两项措施均不受处理的影响。仅在处理的NC100中，后续的组饲养才能进一步降低CORT激活。相比之下，处理导致两条品系中的D1多巴胺受体上调，并且在NC100中，通过组养增加了这种效果。在与另一只雄性小鼠二元相遇中，两条系的受试者均显示出处理效果。 NC100冻结速度较慢，而NC900攻击速度较快。这种多因素设计表明，处理的系统性作用受遗传背景的影响，而这些作用的程度受婴儿期以外经验的影响。我们的发现还表明，在不同的生理系统以及社会和非社会测试条件下进行评估时，处理效果会有所不同。

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