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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of dopamine agonists and antagonists on locomotor activity in male and female rats.
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Effects of dopamine agonists and antagonists on locomotor activity in male and female rats.

机译：多巴胺激动剂和拮抗剂对雄性和雌性大鼠运动能力的影响。

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摘要

Male and female Sprague-Dawley rats were treated with cocaine, the specific dopamine uptake inhibitor GBR 12909, the dopamine D1 agonist SKF 82958 or the dopamine D2 agonist quinpirole. After treatment, the rats were placed in an activity chamber for 30 min and locomotor activity was monitored. Cocaine, GBR 12909 and SKF 82958 all increased locomotor activity in both males and females, but greater increases were observed in females. In contrast, quinpirole produced decreases in activity, with males showing greater decreases than females. Separate groups of animals were given SCH 23390 or eticlopride prior to cocaine. The D1 antagonist SCH 23390 reduced the locomotor activating effects of cocaine in both males and females, with females showing greater sensitivity to SCH 23390. The D2 antagonist eticlopride also reduced the locomotor activating effects of cocaine, with no clear differences between males and females. These results suggest that the differences between males and females in their locomotor response to cocaine can be at least partially attributed to differences in the function of dopamine D1 and D2 receptors.
机译：用可卡因，特异性多巴胺摄取抑制剂GBR 12909，多巴胺D1激动剂SKF 82958或多巴胺D2激动剂喹吡罗处理雄性和雌性Sprague-Dawley大鼠。治疗后，将大鼠置于活动室中30分钟，并监测运动活动。可卡因，GBR 12909和SKF 82958均提高了雄性和雌性的运动能力，但雌性却增加了。相反，喹吡罗产生的活性降低，雄性比雌性表现出更大的降低。在可卡因之前给单独的动物组给予SCH 23390或依替普利特。 D1拮抗剂SCH 23390降低了可卡因在雄性和雌性中的运动激活作用，雌性对SCH 23390表现出更高的敏感性。D2拮抗剂依替洛必德也降低了可卡因的运动激活作用，男女之间没有明显的差异。这些结果表明，男性和女性在可卡因运动反应方面的差异至少可以部分归因于多巴胺D1和D2受体功能的差异。

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