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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of cocaine and putative atypical antipsychotics on rat social behavior. An ethopharmacological study.
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Effects of cocaine and putative atypical antipsychotics on rat social behavior. An ethopharmacological study.

机译：可卡因和推定的非典型抗精神病药对大鼠社交行为的影响。一项民族药理学研究。

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The effects of cocaine, amperozide, clozapine, olanzapine and cocaine/atypical antipsychotic combinations on aggression, affiliation and defensive behaviors was examined. Acute cocaine (30.0 mg/kg) decreased basal aggression and affiliation yet increased basal defense. Amperozide (1.0, 3.0 and 5.0 mg/kg) decreased basal aggression, affiliation and defense had no effect on the cocaine-induced decrease in affiliation, and accentuated the cocaine-induced decrease in aggression. Near basal levels of defense were observed for animals treated with either amperozide, clozapine (3.0 and 10.0 mg/kg but not 30.0 mg/kg) or olanzapine followed by cocaine. Clozapine (3.0, 10.0 and 30.0 mg/kg) decreased basal aggression and affiliation. Clozapine (30.0 mg/kg but not 3.0 or 10.0 mg/kg) decreased basal defense. Clozapine attenuated the cocaine-induced decrease in aggression. Although 3.0 and 10.0 mg/kg clozapine attenuated the cocaine-induced decrease in affiliation, 30.0 mg/kg clozapine accentuated this cocaine-induced effect. Olanzapine (1.0, 3.0 and 10.0 mg/kg) decreased basal aggression, affiliation and defense. Olanzapine had no effect on the cocaine-induced decrease in aggression. Olanzapine (3.0 mg/kg but not 1.0 or 10.0 mg/kg) attenuated the cocaine-induced decrease in affiliation. Thus, acute cocaine administration had an antiaggressive effect, suppressed affiliative behavior and enhanced defensive behavior. Amperozide, clozapine and olanzapine have anticonflict and anxiolytic effects, as well as potent and specific antiaggressive effects.
机译：研究了可卡因，安非他明，氯氮平，奥氮平和可卡因/非典型抗精神病药联合对侵略，隶属关系和防御行为的影响。急性可卡因（30.0 mg / kg）减少了基础攻击和隶属关系，但增强了基础防御能力。 Amperozide（1.0、3.0和5.0 mg / kg）降低了基础攻击性，联盟和防御对可卡因诱导的联盟减少没有影响，并加剧了可卡因诱导的攻击性下降。对于用安非塞德，氯氮平（3.0和10.0 mg / kg，但不是30.0 mg / kg而不是奥氮平）和可卡因治疗的动物，观察到接近基本的防御水平。氯氮平（3.0、10.0和30.0 mg / kg）减少了基础攻击和隶属关系。氯氮平（30.0 mg / kg，但不是3.0或10.0 mg / kg）降低了基础防御能力。氯氮平减轻了可卡因引起的攻击性下降。尽管3.0和10.0 mg / kg的氯氮平减弱了可卡因诱导的从属关系，但30.0 mg / kg的氯氮平增强了这种可卡因诱导的作用。奥氮平（1.0、3.0和10.0 mg / kg）降低了基础攻击性，隶属关系和防御能力。奥氮平对可卡因诱导的攻击性降低没有影响。奥氮平（3.0 mg / kg，但不是1.0或10.0 mg / kg）减轻了可卡因引起的从属关系减少。因此，急性可卡因给药具有抗攻击作用，抑制了亲和行为并增强了防御行为。安培唑，氯氮平和奥氮平具有抗冲突和抗焦虑作用，以及有效的和特定的抗攻击作用。

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