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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents.
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Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents.

机译：通过抑制5-羟色胺再摄取在暴露于新环境的小鼠中诱导超运动。各种抗抑郁药的药理学表征。

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This study characterized the influence of acute administration of diverse classes of antidepressant agent upon the spontaneous locomotor activity (LA) of mice in a novel, open-field environment. The selective serotonin (5-HT) reuptake inhibitors (SSRIs), citalopram, fluoxetine, paroxetine, fluvoxamine, litoxetine and zimelidine, dose-dependently enhanced LA. Their actions were mimicked by the mixed 5-HToradrenaline (NA) reuptake inhibitors (SNRIs), venlafaxine, duloxetine and S33005. In contrast, clomipramine only slightly elevated LA and two further tricyclics, imipramine and amitriptyline, were inactive. Further, the selective NA vs. 5-HT reuptake inhibitors (NARIs), reboxetine, desipramine, maprotiline, nisoxetine and nortriptyline all failed to increase LA. The "atypical antidepressants," mianserin and mirtazapine, neither of which modify 5-HT reuptake, as well as the mixed SSRI/5-HT(2) antagonists, nefazodone and trazodone, also failed to increase LA. Doses of SSRI and SNRI which increased LA did not modify motor performance in the rotarod test. Further, they did not enhance LA in rats, suggesting that this response is characteristic of mice. Finally, upon prehabituation of mice to the activity chamber, the SSRI, citalopram, and the SNRI, venlafaxine, failed to increase LA. In conclusion, in mice exposed to a novel environment, inhibition of 5-HT reuptake by SSRIs and SNRIs enhances spontaneous LA in the absence of a generalized influence upon motor function. This response provides a simple parameter for characterization of SSRIs and SNRIs, and differentiates them from other classes of antidepressant agent. Although an influence upon arousal and/or anxiety is likely related to the increase in LA, the functional significance of this response requires additional elucidation.
机译：这项研究的特点是在新型的开放视野环境中，急性给予不同种类的抗抑郁药对小鼠自发运动能力（LA）的影响。选择性5-羟色胺（5-HT）再摄取抑制剂（SSRIs），西酞普兰，氟西汀，帕罗西汀，氟伏沙明，利托西汀和齐美替丁，剂量依赖性地增强了LA。混合的5-HT /去甲肾上腺素（NA）再摄取抑制剂（SNRIs），文拉法辛，度洛西汀和S33005模仿了它们的作用。相反，氯米帕明仅使LA轻度升高，另外两个三环类药物丙咪嗪和阿米替林则没有活性。此外，选择性NA对5-HT再摄取抑制剂（NARI），瑞波西汀，地昔帕明，马普替林，尼索西汀和去甲替林均不能增加LA。 “非典型抗抑郁药”，米安色林和米氮平，都不改变5-HT的再摄取，以及混合的SSRI / 5-HT（2）拮抗剂奈法唑酮和曲唑酮，也未能增加LA。在轮式试验中，增加LA的SSRI和SNRI剂量并未改变电机性能。此外，它们没有增强大鼠的LA，表明这种反应是小鼠的特征。最终，在将小鼠预先适应活动室后，SSRI，西酞普兰和SNRI，文拉法辛不能增加LA。总之，在暴露于新环境的小鼠中，SSRI和SNRI对5-HT再摄取的抑制作用增强了自发性LA，而对运动功能没有普遍影响。该响应提供了表征SSRI和SNRI的简单参数，并将它们与其他类型的抗抑郁药区分开来。尽管对唤醒和/或焦虑的影响可能与LA的升高有关，但该反应的功能重要性还需要进一步阐明。

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