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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils.
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Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils.

机译：氟沙啶引起的癫痫发作的特征以及抗癫痫药对蒙古沙鼠沙丁胺醇引起的癫痫发作的作用。

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摘要

We investigated the characteristics of the flurothyl-induced seizures and the effects of antiepileptic drugs on the flurothyl-induced seizure model in a previously untested Mongolian gerbil species. Mongolian gerbils demonstrated tonic extension immediately after or within 1 min after the appearance of clonic convulsion. Very high amplitude spike waves appeared in these regions concurrent with the appearance of clonic convulsion. When the tonic extension appeared immediately after the clonic convulsion, the high amplitude spike waves continued during tonic convulsion. When the tonic extension occurred, high amplitude spike waves appeared in these three regions within a very short time, and afterward Mongolian gerbils died. Administration of valproic acid-Na (200 mg/kg), ethosuximide (100 and 200 mg/kg), clonazepam (2 mg/kg) and diazepam (0.5, 1 and 2 mg/kg) significantly prolonged the latency of clonic convulsion. Zonisamide-Na, phenytoin and carbamazepine, however, had no such effect. In Mongolian gerbils, tonic extension was demonstrated immediately after the appearance of clonic convulsion, yet, this effect was inhibited by all these drugs in a dose-dependent manner. Diazepam completely blocked the appearance of any behavioral changes in animals. These findings suggest that diazepam has a significant effect on flurothyl-induced seizures. Flurothyl-induced convulsions are associated with GABA receptors; hence, benzodiazepine (BDP) suppression may result from the strong relation between BDP and GABAnergic neurons.
机译：我们调查了氟乙基诱导的癫痫发作的特征以及抗癫痫药对氟乙基诱导的癫痫发作模型的影响，该模型先前未经测试，蒙古沙鼠物种。蒙古沙鼠在阵挛性抽搐出现后立即或在1分钟内表现出强直性扩张。在这些区域出现高振幅的尖峰波，并出现阵挛性抽搐。当阵挛性抽搐后立即出现强直性扩张时，在强直性惊厥期间继续出现高振幅的尖峰波。当发生强直扩展时，这三个区域在很短的时间内出现了高振幅的尖峰波，随后蒙古沙鼠死亡。给予丙戊酸钠（200 mg / kg），乙乙酰亚胺（100和200 mg / kg），氯硝西am（2 mg / kg）和地西epa（0.5、1和2 mg / kg）可以显着延长阵挛性抽搐的潜伏期。但是，唑尼沙胺钠，苯妥英钠和卡马西平没有这种作用。在蒙古沙鼠中，在阵挛性抽搐出现后立即表现出强直性扩展，然而，所有这些药物均以剂量依赖的方式抑制了这种作用。地西p完全阻止了动物行为变化的出现。这些发现表明地西epa对氟尿嘧啶引起的癫痫发作具有显著作用。氟乙啶引起的惊厥与GABA受体有关。因此，苯二氮卓（BDP）抑制可能是由于BDP与GABA能神经元之间的密切关系所致。

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