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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral sensitization to amphetamine follows chronic administration of the CB(1) agonist WIN 55,212-2 in Lewis rats.
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Behavioral sensitization to amphetamine follows chronic administration of the CB(1) agonist WIN 55,212-2 in Lewis rats.

机译：对苯丙胺的行为致敏作用是在Lewis大鼠中长期施用CB（1）激动剂WIN 55,212-2。

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摘要

The extent to which acute and repeated administration of the CB(1) agonist WIN 55,212-2 would affect the stimulatory properties of amphetamine was assessed in Lewis rats. In the first experiment, Lewis rats were treated with either 1 mg/kg of WIN 55,212-2 or vehicle and subsequently treated with 2 mg/kg amphetamine. Acute treatment with WIN 55,212-2 initially increased locomotor activity and then attenuated the stimulating effect of amphetamine on locomotion and exploration (as measured by rears). In a separate experiment, Lewis rats were given daily injections of either WIN 55,212-2 (1 mg/kg) or vehicle for 10 days and the effects of amphetamine were assessed at 1 and 3 days following the last chronic cannabinoid treatment. Those rats, which had been treated with WIN 55,212-2, had an enhanced response to amphetamine with rearing but not with ambulatory movements, suggesting the occurrence of behavioral cross-sensitization to the ability of amphetamine to increase rearing. These data add to the growing evidence that there is at least some overlap between those neural systems acted upon by cannabinoids and those that are believed to be involved in incentive properties associated with other drugs of abuse.
机译：在Lewis大鼠中评估了CB（1）激动剂WIN 55,212-2的急性和反复给药对苯丙胺的刺激特性的影响程度。在第一个实验中，用1 mg / kg的WIN 55,212-2或溶媒治疗Lewis大鼠，然后用2 mg / kg的苯丙胺治疗。用WIN 55,212-2进行的急性治疗最初会增加运动能力，然后减弱苯丙胺对运动和探索的刺激作用（通过后方测量）。在另一项实验中，每天给Lewis大鼠注射WIN 55,212-2（1 mg / kg）或赋形剂10天，并在最后一次慢性大麻素治疗后1和3天评估苯丙胺的作用。那些用WIN 55,212-2治疗的大鼠在饲养时对苯丙胺具有增强的反应，但在步行运动时却没有，表明存在对苯丙胺增加饲养的能力的行为交叉敏化。这些数据增加了越来越多的证据，表明大麻素作用的神经系统与那些被认为与其他滥用药物有关的刺激特性有关的神经系统之间至少存在一些重叠。

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