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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of imipramine on the expression and acquisition of morphine-induced conditioned place preference in mice.
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Effect of imipramine on the expression and acquisition of morphine-induced conditioned place preference in mice.

机译：丙咪嗪对小鼠吗啡诱导的条件性位置表达的表达和获取的影响。

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The effect of imipramine and alpha-adrenoceptor agonists and antagonists on the acquisition or expression of morphine-induced conditioned place preference (CPP) was studied in mice. An unbiased CPP paradigm was used to study the effect of the agents. In the first set of experiments, the drugs were used during the development of CPP by morphine or they were used alone in order to see if they induce CPP or conditioned place aversion (CPA). Our data showed that intraperitoneal injection of morphine sulphate (2.5-10 mg/kg) induced CPP in mice. Imipramine (0.5-2.5 mg/kg), phenylephrine (0.5-2 mg/kg), yohimbine (0.5-2 mg/kg) or prazosin (0.1-1 mg/kg) did not influence CPP, but clonidine (0.002-0.05 mg/kg) induced CPA. Yohimbine increased, while clonidine and prazosin reversed, morphine-induced CPP. Phenylephrine did not influence the CPP induced by morphine. In the second set of experiments, when the drugs were used before testing on Day 6, in order to test their effects on the expression of morphine-induced CPP, imipramine (0.5-5 mg/kg) reversed morphine-induced CPP and this reversal was blocked by naloxone (2 mg/kg). Clonidine and prazosin reversed, while yohimbine decreased morphine-induced CPP. Phenylephrine did not alter the morphine response. Furthermore, yohimbine and prazosin reversed the imipramine effect. None of the drugs influenced locomotion. However, prazosin or yohimbine in combination with morphine altered locomotor activity during the acquisition of CPP. Yohimbine by itself increased locomotion. It is concluded that imipramine can induce CPA through an opioid receptor mechanism and alpha-adrenoceptor agents may influence morphine CPP.
机译：在小鼠中研究了丙咪嗪和α-肾上腺素受体激动剂和拮抗剂对吗啡诱导的条件性位置偏爱（CPP）的获得或表达的影响。使用无偏CPP范式来研究药剂的作用。在第一组实验中，吗啡在CPP形成过程中使用了这些药物，或者单独使用这些药物是为了查看它们是否诱导CPP或条件性位置反感（CPA）。我们的数据显示，腹腔内注射硫酸吗啡（2.5-10 mg / kg）可诱发小鼠CPP。丙咪嗪（0.5-2.5 mg / kg），去氧肾上腺素（0.5-2 mg / kg），育亨宾（0.5-2 mg / kg）或哌唑嗪（0.1-1 mg / kg）不会影响CPP，但可乐定（0.002-0.05） mg / kg）诱导的CPA。育亨宾增加，而可乐定和哌唑嗪逆转，吗啡诱导的CPP。苯肾上腺素不影响吗啡诱导的CPP。在第二组实验中，在第6天测试之前使用药物时，为了测试其对吗啡诱导的CPP表达的影响，丙咪嗪（0.5-5 mg / kg）逆转了吗啡诱导的CPP，并且这种逆转被纳洛酮（2 mg / kg）阻断。可乐定和哌唑嗪逆转，而育亨宾降低吗啡诱导的CPP。苯肾上腺素不会改变吗啡反应。此外，育亨宾和哌唑嗪逆转了丙咪嗪的作用。没有一种药物影响运动。然而，哌唑嗪或育亨宾与吗啡的结合在CPP的获得过程中改变了运动活性。育亨宾本身增加了运动。结论是丙咪嗪可以通过阿片受体机制诱导CPA，α-肾上腺素受体药物可以影响吗啡CPP。

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