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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Vaginal lavage attenuates cocaine-stimulated activity and establishes place preference in rats.
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Vaginal lavage attenuates cocaine-stimulated activity and establishes place preference in rats.

机译：阴道灌洗减弱了可卡因刺激的活动，并在大鼠中建立了位置偏好。

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摘要

Sex and estrous cycle stage affect psychostimulant responses in animals. Cycle stage is typically monitored by vaginal lavage. The present studies tested the hypothesis that vaginal lavage modifies behavioral responses to acute cocaine. Female rats were restrained by briefly holding the tail for either vaginal lavage or touching the thigh, or were undisturbed, for 7-10 days prior to testing. Although habituation to the open-field test chamber was equal in each group, repeated lavage decreased horizontal activity relative to naive rats following acute cocaine (10 mg/kg ip). Lavage and touch attenuated cocaine-stimulated vertical activity. A single lavage prior to testing did not affect cocaine-stimulated motor behavior. Estrous cycle influenced motor activity only in nonlavaged rats. The high cocaine-induced responding observed in proestrous and estrous nonlavaged rats was completely blocked by vaginal lavage. A separate experiment tested the ability of vaginal lavage to establish a conditioned place preference. Vaginal lavage immediately prior to the conditioning session, but neither lavage after conditioning nor touch before, induced a significant preference. These results suggest that vaginal lavage serves as a reinforcing stimulus and interacts with a neural substrate that mediates enhanced locomotor responses to cocaine during proestrus and estrus.
机译：性和发情周期阶段会影响动物的精神兴奋反应。周期阶段通常通过阴道灌洗来监测。本研究检验了阴道灌洗改变对可卡因的行为反应的假说。在测试前，通过短暂握住尾巴进行阴道灌洗或触摸大腿来约束雌性大鼠，或者使其不受干扰。尽管在每组中进入野外试验室的习惯均相等，但相对于幼稚大鼠服用急性可卡因（10 mg / kg ip）后，反复灌洗会降低其水平活动。灌洗和触摸减弱了可卡因刺激的垂直活动。测试前一次灌洗不影响可卡因刺激的运动行为。发情的周期仅影响非活动大鼠的运动活动。在发情和发情的非灌胃大鼠中观察到的高可卡因诱导的反应被阴道灌洗完全阻断。另一个实验测试了阴道灌洗建立条件性位置偏爱的能力。紧接调理之前的阴道灌洗，但调理后和之前均未洗手均引起明显的偏爱。这些结果表明，阴道灌洗是一种增强刺激，并与神经基质相互作用，该神经基质在发情和发情期间介导对可卡因的运动反应增强。

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