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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hypothalamic paraventricular 5-hydroxytryptamine: Receptor-specific inhibition of NPY-stimulated eating and energy metabolism.
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Hypothalamic paraventricular 5-hydroxytryptamine: Receptor-specific inhibition of NPY-stimulated eating and energy metabolism.

机译：下丘脑室旁5-羟色胺：NPY刺激饮食和能量代谢的受体特异性抑制。

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摘要

The feeding effects of 5-hydroxytryptamine (5-HT)(1) and 5-HT(2) receptor agonists injected into the hypothalamic paraventricular nucleus (PVN) immediately prior to PVN administration of neuropeptide Y (NPY) were examined. The impact of these same compounds on NPY-induced alterations in energy metabolism was also assessed in an attempt to characterize further the potential interactive relationship of PVN NPY and 5-HT on feeding and whole body calorimetry. Specifically, several experiments examined the effect of various 5-HT receptor agonists on NPY-stimulated eating and alterations in energy substrate utilization [respiratory quotient (RQ)]. This included the 5-HT(1A) receptor agonist 8-OH-DPAT, the 5-HT(1B/1A) agonist RU 24969, the 5-HT(1D) agonist L-694,247, the 5-HT(2A/2C) agonist DOI, the 5-HT(2B) agonist BW 723C86 and the 5-HT(2C) agonist mCPP. In feeding tests conducted at the onset of the dark cycle, drugs were administered 5 min prior to PVN injection of NPY and food intake was measured 2 h postinjection. The metabolic effects of NPY following a similar pretreatment were monitored using an open-circuit calorimeter measuring the volume of oxygen consumed (VO(2)), carbon dioxide produced (VCO(2)) and RQ (VCO(2)/VO(2)). PVN injection of NPY (100 pmol) potentiated feeding and evoked reliable increases in RQ. Only DOI (2.5--5 nmol) pretreatment antagonized NPY-induced eating and blocked the peptide's effect on energy substrate utilization. Direct PVN pretreatment with spiperone (SPRN), a 5-HT(2A) receptor antagonist, and ketanserin (KTSN), a 5-HT(2A/2C) antagonist, but not SDZ SER 082, a 5-HT(2B/2C) antagonist, or the 5-HT(2C) antagonist RS 102221, blocked the effect of DOI in both feeding and metabolic tests providing additional evidence that activation of PVN 5-HT(2A) receptors inhibits NPY's action on feeding and substrate utilization.
机译：检查了在即将对神经肽Y（NPY）进行PVN给药之前注入下丘脑室旁核（PVN）的5-羟色胺（5-HT）（1）和5-HT（2）受体激动剂的进食效果。还评估了这些相同化合物对NPY诱导的能量代谢改变的影响，以试图进一步表征PVN NPY和5-HT在进食和全身热量测定方面的潜在相互作用关系。具体而言，一些实验检查了各种5-HT受体激动剂对NPY刺激的进食和能量底物利用率变化的影响[呼吸商（RQ）]。其中包括5-HT（1A）受体激动剂8-OH-DPAT，5-HT（1B / 1A）激动剂RU 24969、5-HT（1D）激动剂L-694,247、5-HT（2A / 2C ）激动剂DOI，5-HT（2B）激动剂BW 723C86和5-HT（2C）激动剂mCPP。在黑暗周期开始时进行的进食测试中，在PVN注射NPY前5分钟给药药物，并在注射后2小时测量食物摄入量。 NPY的类似预处理后的代谢作用是使用开路热量计监测的，该热量计测量消耗的氧气（VO（2）），产生的二氧化碳（VCO（2））和RQ​​（VCO（2）/ VO（2） ））。 NPY（100 pmol）的PVN注射增强了进食并引起RQ的可靠增加。只有DOI（2.5--5 nmol）预处理可拮抗NPY诱导的进食，并阻止该肽对能量底物利用率的影响。直接使用氟哌啶酮（SPRN），5-HT（2A）受体拮抗剂和酮色林（KTSN），5-HT（2A / 2C）拮抗剂但不使用SDZ SER 082、5-HT（2B / 2C）进行直接PVN预处理拮抗剂或5-HT（2C）拮抗剂RS 102221阻断了DOI在饲喂和代谢测试中的作用，从而提供了更多证据表明PVN 5-HT（2A）受体的激活会抑制NPY对饲料和底物利用的作用。

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