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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Modulation of spatial alternation and anxiety by septal scopolamine systemic diazepam in mice.
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Modulation of spatial alternation and anxiety by septal scopolamine systemic diazepam in mice.

机译：间隔东pol碱系统地西epa在小鼠中对空间交替和焦虑的调节。

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摘要

To investigate the behavioral consequences of benzodiazepines in subjects whose septo-hippocampal cholinergic (ACh) activity was impaired, C57BL/6 mice received an injection of 2.5 microg/0.2 microl of scopolamine into the medial septal area with an i.p. injection of 0.5 mg/kg of diazepam. The consequences of these treatments administered in combination or alone were evaluated on anxiety measured in an elevated plus-maze and on spontaneous alternation carried out in a T-maze, using two different intertrial intervals (ITI: 5s or 30s). In these conditions, only the combined treatment provoked a decrease of the anxiety level, which was associated with an impairment of spontaneous alternation restricted to the 5s ITI. Because mice were not impaired during the sequential 30s ITI, this seems to rule out the possibility that this alternation deficit resulted from a working memory loss. These results suggest an involvement of a septal ACh-GABA-A/BDZ interaction in the exaggeration of cognitive deficits produced by benzodiazepines in patients characterized by a cholinergic hypofunction.
机译：为了研究苯二氮卓类药物对中隔海马胆碱能（ACh）活性受损的受试者的行为后果，C57BL / 6小鼠接受腹膜内中隔区注射2.5 microg / 0.2 microl东sep碱。注射0.5 mg / kg地西epa。使用两个不同的试验间隔（ITI：5s或30s），对在升高的迷宫中测得的焦虑和在T迷宫中进行的自发交替进行评估，评估了这些组合治疗或单独治疗的后果。在这些情况下，只有联合治疗才引起焦虑水平的降低，这与限于5s ITI的自发性交变障碍有关。因为小鼠在连续的30s ITI期间没有受到损伤，所以这似乎排除了这种交替缺陷是由于工作记忆丧失而引起的。这些结果表明，在以胆碱能功能减退为特征的患者中，间隔性ACh-GABA-A / BDZ相互作用参与了苯二氮卓类药物所引起的认知功能障碍。

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