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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neonatal scopolamine or antidepressant treatment: effect on development of hamster circadian rhythms.
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Neonatal scopolamine or antidepressant treatment: effect on development of hamster circadian rhythms.

机译：新生儿东pol碱或抗抑郁药治疗：对仓鼠昼夜节律发展的影响。

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Chronic treatment of young rodents with drugs altering monoamine metabolism has been reported to produce lasting effects on behavior that resemble human affective disorders. To test the generality of this finding, scopolamine, imipramine, or clomipramine was injected daily between the ages of 8 and 21 days in golden hamsters. Wheel-running rhythms were monitored continuously from the age of 4 to 20 weeks of age to test the hypothesis that neonatal treatments would lower the amplitude of biological activity rhythms in adults. Of these three neonatal treatments only scopolamine altered running rhythms, significantly increasing the amplitude of running rhythms in adult hamsters under both entrained and free-running conditions. Hamsters treated neonatally with scopolamine were also more sensitive to the hypothermic effects of the muscarinic agonist, oxotremorine, as adults. These data indicate that neonatal exposure to cholinergic receptor blockade may produce long-lasting changes in biological rhythm characteristics related to upregulation of muscarinic receptors.
机译：据报道，用改变单胺代谢的药物对年轻啮齿类动物进行长期治疗会对类似于人类情感障碍的行为产生持久影响。为了检验这一发现的普遍性，每天在8至21天的金黄仓鼠中注射东pol碱，丙咪嗪或氯米帕明。从4周到20周的年龄连续监测车轮行驶的节奏，以检验以下假设：新生儿治疗会降低成年人的生物活动节奏的幅度。在这三种新生儿治疗中，只有东pol碱可改变跑步节奏，从而在成年和自由跑步条件下显着增加成年仓鼠跑步节奏的幅度。成年后，用东pol碱新生儿处理过的仓鼠对毒蕈碱激动剂oxotremorine的低温效应也更为敏感。这些数据表明，新生儿暴露于胆碱能受体阻滞可能会导致与毒蕈碱受体上调相关的生物节律特征发生长期变化。

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