首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Stress and a glycinergic intervention interact in the modulation of MK-801-elicited mouse popping behavior.
【24h】

Stress and a glycinergic intervention interact in the modulation of MK-801-elicited mouse popping behavior.

机译:压力和甘氨酸干预在MK-801引起的小鼠弹出行为的调节中相互作用。

获取原文
获取原文并翻译 | 示例
           

摘要

The ability of D-cycloserine, a partial glycine agonist, to modulate mouse popping behavior elicited by MK-801, a noncompetitive NMDA receptor antagonist, was studied in unstressed and stressed mice. In unstressed animals, D-cycloserine (5.6 and 10 mg/kg) attenuated the ability of MK-801 (1.0 mg/kg) to elicit this behavior. However, the ability of D-cycloserine to attenuate MK-801-elicited mouse-popping behavior was not evident in stressed mice, 24 h after they were forced to swim for up to 10 min in cold water. Thus, the therapeutic value of glycinergic interventions may be limited by environmental factors, such as stress.
机译:在非应激和应激小鼠中研究了D-环丝氨酸(一种部分甘氨酸激动剂)调节由非竞争性NMDA受体拮抗剂MK-801引起的小鼠弹跳行为的能力。在无压力的动物中,D-环丝氨酸(5.6和10 mg / kg)减弱了MK-801(1.0 mg / kg)引起这种行为的能力。但是,D-环丝氨酸减弱MK-801引起的小鼠弹出行为的能力在压力小鼠中不明显,在强迫小鼠在冷水中游泳长达10分钟后24小时。因此,甘氨酸能干预的治疗价值可能受到环境因素(例如压力)的限制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号