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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures.
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Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures.

机译：通过药物区分程序了解乙醇的药理作用的策略。

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摘要

Ethanol appears to produce a stimulus complex, or compound cue, composed of distinct components that are mediated by different receptor systems. In ethanol vs. water discriminations, it appears that ethanol produces a redundant stimulus complex such that separate, receptor-mediated activity can serve as the basis for the discrimination. These discriminations have been termed redundant, because multiple features of the cue could serve as the basis of the discrimination. In ethanol vs. water discriminations, one common feature is the asymmetrical generalizations between components of the ethanol cue and ethanol. There is also evidence for overshadowing of one component by other components of the ethanol stimulus complex. It appears possible to transfer the basis of the ethanol cue from a redundant cue to a conditional cue with specific training procedures. When the discriminative stimulus effects of ethanol are juxtoposed with those of one component of the ethanol complex, as in ethanol vs. water vs. pentobarbital discriminations, the ethanol discrimination shifts to a conditional basis. The ability to antagonize an ethanol discrimination may be dependent upon whether the discrimination is based on redundant component stimuli or conditional presence of all component stimuli.
机译：乙醇似乎会产生由不同受体系统介导的独特成分组成的刺激复合物或复合信号。在乙醇与水的判别中，似乎乙醇会产生多余的刺激复合物，因此单独的，受体介导的活性可以作为判别的基础。这些区分被称为多余的，因为提示的多个特征可以用作区分的基础。在乙醇与水的判别中，一个共同的特征是乙醇提示与乙醇之间的不对称泛化。也有证据表明乙醇刺激复合物的一种组分被其他组分掩盖。通过特定的训练程序，似乎可以将乙醇提示的基础从冗余提示转换为条件提示。当乙醇的鉴别刺激效果与乙醇复合物的一种成分的鉴别刺激效果并列时，例如在乙醇与水，戊巴比妥鉴别中，乙醇的鉴别转移到有条件的基础上。对抗乙醇歧视的能力可能取决于歧视是基于多余的组分刺激还是所有组分刺激的条件存在。

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