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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Isradipine combined with naltrexone persistently reduces the reward-relevant effects of cocaine and alcohol.
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Isradipine combined with naltrexone persistently reduces the reward-relevant effects of cocaine and alcohol.

机译：依拉地平联合纳曲酮会持续降低可卡因和酒精与奖励有关的作用。

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摘要

Previous studies have revealed that the combination of small doses of isradipine and naltrexone (ISR&NTX) blocks the ability of cocaine to enhance pressing for rewarding, lateral hypothalamic brain stimulation. Further, such combinations also reduce rats' intakes of alcoholic beverages. Here, we asked whether ISR&NTX would lose its ability to reduce the reinforcing effects of cocaine and alcohol when given daily. Specifically, after almost 2 months of daily injections, ISR&NTX blocked the expression of a cocaine-induced conditioned place preference (CPP). By themselves, ISR and NTX were not effective at blocking cocaine's effects. Subsequent to the CPP procedures, the rats continued to receive daily injections for another 3 weeks. During this time, they were given access to water and an alcoholic beverage for 2 h a day. As expected, placebo controls gradually increased their daily intakes until they were taking about 2 g/kg of ethanol daily. ISR, NTX, and ISR&NTX blocked the typical pattern of intakes. At the end of the 3-week period, the rats had received 80 consecutive daily injections. The data suggest that the salient effects of ISR&NTX do not wane. The data support the idea that ISR&NTX would be a useful pharmacotherapy for poly drug abuse.
机译：先前的研究表明，小剂量的伊拉地平和纳曲酮（ISR＆NTX）的结合会阻止可卡因增强对下丘脑外侧刺激的压力。此外，这样的组合也减少了大鼠酒精饮料的摄入。在这里，我们问ISR＆NTX每天服用时是否会失去降低可卡因和酒精增强作用的能力。具体来说，每天注射将近2个月后，ISR＆NTX阻止了可卡因诱导的条件性位置偏爱（CPP）的表达。 ISR和NTX本身无法有效阻断可卡因的作用。在CPP程序之后，大鼠继续接受每日注射另外3周。在这段时间里，他们每天有2小时可以喝水和酒精饮料。如预期的那样，安慰剂对照逐渐增加其每日摄入量，直到他们每天摄入约2 g / kg的乙醇。 ISR，NTX和ISR＆NTX阻止了典型的摄入模式。在3周的时间结束时，大鼠已连续接受80次每日注射。数据表明，ISR＆NTX的显着影响没有减弱。数据支持ISR＆NTX将是一种有用的药物治疗多药滥用的想法。

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