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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
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Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.

机译：大鼠颞下颌关节发炎/疼痛相关的膳食模式变化;镇痛作用。

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Establishing a valid animal model to study temporomandibular joint (TMJ) pain has proven extremely difficult. Using complete Freund's adjuvant (CFA) to induce TMJ inflammation, we recently showed that meal pattern analysis could be used as a noninvasive biological marker to study TMJ pain in an animal model. The purpose of this study was to further validate our animal model by determining whether aspects of CFA-induced TMJ inflammation/pain are reversed with ibuprofen (IBU) treatment. In the first trial, 48 male rats were used and in the second trial, 32 female ovariectomized rats, given 17beta-estradiol replacement, were used. The rats were assigned to one of four groups: control (CON-CON); control+IBU (CON+IBU); CFA-CON; and CFA+IBU. In the male trial, CFA injection (P<.01) caused TMJ swelling and chromodacryorrhea (CFA-CON); IBU eliminated these changes in the CFA+IBU group. Meal pattern analysis showed the pertinent CFA-induced change and the IBU effect was that meal duration was increased in the CFA-CON group (P<.01), but normal in the CFA+IBU-treated group on the first, but not second, day postinjection. In the female trial, CFA increased TMJ swelling, but did not cause significant chromodacryorrhea (CFA-CON); IBU eliminated swelling in the CFA+IBU group. Meal duration was increased (P<.01) in the CFA-CON group, but was normal in the CFA+IBU-treated group on both the first and second days postinjection. In both trials, interleukin-1beta (IL-1beta) levels were increased similarly in CFA-CON and CFA+IBU groups (P<.01). This study shows that CFA-induced TMJ inflammation/pain can cause changes in meal patterns (i.e., meal duration), which may be used as a behavioral marker for TMJ inflammation/pain.
机译：建立有效的动物模型来研究颞下颌关节（TMJ）疼痛已被证明极为困难。最近，我们使用完全弗氏佐剂（CFA）诱发TMJ炎症，表明膳食模式分析可以用作研究动物模型TMJ疼痛的一种非侵入性生物学标记。这项研究的目的是通过确定布洛芬（IBU）治疗是否可以逆转CFA诱导的TMJ炎症/疼痛方面来进一步验证我们的动物模型。在第一项试验中，使用了48只雄性大鼠，在第二项试验中，使用了接受17β-雌二醇替代的32只雌性去卵巢大鼠。将大鼠分为四组之一：对照组（CON-CON）;对照组（对照组）。控制+ IBU（CON + IBU）; CFA-CON;和CFA + IBU。在男性试验中，注射CFA（P <.01）导致TMJ肿胀和色带增多（CFA-CON）。 IBU消除了CFA + IBU组中的这些更改。进餐模式分析显示CFA引起的相关变化，并且IBU的作用是CFA-CON组进餐时间延长（P <.01），但在CFA + IBU治疗组中进餐时间正常，但第二次却没有，注射后一天。在该女性试验中，CFA增加了TMJ肿胀，但并未引起显着的色带增多症（CFA-CON）。 IBU消除了CFA + IBU组的肿胀。在注射后的第一天和第二天，CFA-CON组的进餐时间增加（P <.01），但在CFA + IBU治疗组中，进餐时间是正常的。在这两个试验中，CFA-CON组和CFA + IBU组的白细胞介素1beta（IL-1beta）水平均类似升高（P <.01）。这项研究表明，CFA诱发的TMJ炎症/疼痛可引起进餐模式的变化（即进餐持续时间），可用作TMJ炎症/疼痛的行为指标。

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