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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A synthetic peptide ligand of NCAM affects exploratory behavior and memory in rodents.
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A synthetic peptide ligand of NCAM affects exploratory behavior and memory in rodents.

机译：NCAM的合成肽配体影响啮齿动物的探索行为和记忆。

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摘要

The neural cell adhesion molecule (NCAM) is an important modulator of neuronal development and plasticity associated with learning and memory. Previously, a synthetic peptide ligand of NCAM, called C3, has been identified and shown to modulate neuronal plasticity in vitro and memory in a step-through passive avoidance task in rats in vivo. In this study, we extended these findings and found that intraventricular injection of C3 prior to training impaired learning or memory processes in rats and mice in an approach avoidance task and decreased exploratory behavior in rats. The effect of C3 was additionally evaluated in the Morris water maze; memory impairment was observed in the second training trial 24 h after the injection of C3 only, indicating an effect on short-term memory. The C3-mediated memory impairment observed in the approach avoidance and water maze tests is suggested to be the result of C3-inhibiting NCAM functions in the brain. This study demonstrates that it is possible to modulate learning/memory processes in rodents in vivo with small synthetic NCAM-binding peptides that induce developmental plasticity in vitro.
机译：神经细胞粘附分子（NCAM）是与学习和记忆有关的神经元发育和可塑性的重要调节剂。以前，已经鉴定出一种称为C3的NCAM合成肽配体，并显示出它可以在大鼠体内通过逐步被动回避任务来调节体外神经元可塑性和记忆。在这项研究中，我们扩展了这些发现，并发现在进场回避任务中，在训练大鼠和小鼠的学习或记忆过程之前，先进行脑室内注射C3会损害大鼠的探索行为。另外在莫里斯水迷宫中评估了C3的作用。仅注射C3后24小时，在第二次训练试验中观察到记忆障碍，表明对短期记忆有影响。在避免进近和水迷宫测试中观察到的C3介导的记忆障碍被认为是大脑中C3抑制NCAM功能的结果。这项研究表明，可以利用诱导体外发育可塑性的小型合成NCAM结合肽在体内调节啮齿动物的学习/记忆过程。

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