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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of angiotensin IV on the acquisition of the water maze task and ryanodine channel function.
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Effect of angiotensin IV on the acquisition of the water maze task and ryanodine channel function.

机译：血管紧张素IV对获得水迷宫任务和ryanodine通道功能的影响。

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摘要

In the present study, we investigated the effect of angiotensin IV (Ang IV) on the acquisition of spatial task by rats, expression and function of ryanodine receptors (RyRs) and on Ca(2+) transport in microsomal membranes isolated from rat hippocampus, the brain structure essential for spatial memory.Wistar rats, injected intracerebroventricularly with 1 nmol of Ang IV or saline were subjected to the water maze training using hidden (learning) or visible (nonlearning) escape platform. Rats showed overall good acquisition of the task and mean escape latency decreased from 55 s to less than 10 s during the 5-day training. Learning significantly increased [3H]-ryanodine binding to microsomal RyRs and markedly decreased both receptor affinity constant for the ligand and microsomal Ca(2+) uptake. Ang IV was without effect on the rate of acquisition of the spatial task but increased (by 47%) maximal ryanodine binding in hippocampal microsomes of the trained rats. The peptide, however, did not affect decreased net Ca(2+) uptake in rats subject to learning procedure. Since microsomal Ca(2+)-ATPase activity was similar in all tested groups, the lower net Ca(2+) uptake in the trained rats could be attributed to the elevated expression of RyRs and resulting to increased Ca(2+) release.
机译：在本研究中，我们研究了血管紧张素IV（Ang IV）对大鼠获得空间任务，ryanodine受体（RyRs）的表达和功能以及Ca（2+）在大鼠海马微粒体膜中转运的影响，脑室注射1 nmol的Ang IV或盐水对Wistar大鼠进行隐性（学习）或可见（非学习）逃生平台水迷宫训练。在5天的训练中，大鼠表现出对任务的总体良好接受，平均逃避潜伏期从55 s减少至不到10 s。学习显着增加[3H] -ryanodine与微粒体RyRs的结合，并显着降低配体和微粒体Ca（2+）吸收的受体亲和常数。血管紧张素IV对空间任务的获得率没有影响，但在训练大鼠的海马微粒体中最大莱丹定结合增加（增加了47％）。然而，该肽并不影响大鼠学习过程中的净Ca（2+）摄取减少。由于微粒体的Ca（2 +）-ATPase活性在所有测试组中均相似，因此在训练大鼠中较低的净Ca（2+）摄取可归因于RyRs的表达升高并导致Ca（2+）释放增加。

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