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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia.
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Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia.

机译：苯丙胺致敏的大鼠表现出糖诱导的过度活跃（交叉致敏）和糖过多症。

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摘要

The goal was to determine the locomotor and consummatory effects of sugar in amphetamine-sensitized rats. Following a 30-min locomotor activity baseline using a photocell cage, male rats were administered either 3.0 mg/kg amphetamine or saline i.p. daily for 6 days. On the final day of injections, locomotor activity was measured again to affirm amphetamine sensitization. Experiment 1: Seven days later, half of each group was offered 10% sucrose or water for 1 min in the home cages, followed by a 30-min locomotor activity test to determine whether or not the animals had become hyperactive in response to sugar. Results showed that amphetamine-sensitized animals were hyperactive following a taste of sugar, but not water. Experiment 2: All subjects were then given access to 10% sucrose for 1 h daily for five consecutive days. Results showed that the amphetamine-sensitized group consumed more sucrose across the 5-day measurement period. These results suggest that sugar may be acting on the same system as amphetamine to trigger hyperactivity, and that alterations in this system caused by repeated doses of amphetamine can instigate an appetite for sugar that persists for at least a week.
机译：目的是确定糖在苯丙胺致敏的大鼠中的运动和改善作用。使用光电池笼进行30分钟的运动活动基线后，对雄性大鼠进行3.0 mg / kg安非他明或生理盐水腹腔注射。每天6天。在注射的最后一天，再次测量运动活性以确认苯丙胺敏化。实验1：7天后，每组一半在家笼中提供10％蔗糖或水1分钟，然后进行30分钟运动能力测试，以确定动物是否对糖有反应。结果表明，苯丙胺敏化的动物在吃了糖而不是水后变得活跃。实验2：然后让所有受试者连续1天每天服用1％的10％蔗糖。结果表明，苯丙胺敏化组在5天的测量期内消耗了更多的蔗糖。这些结果表明，糖可能与苯丙胺在相同的系统上起作用，从而触发机能亢进，并且由于重复剂量的苯丙胺而引起的该系统的改变可以激发食欲，糖食持续至少一周。

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