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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral and analgesic effects induced by administration of nifedipine and nimodipine.
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Behavioral and analgesic effects induced by administration of nifedipine and nimodipine.

机译：硝苯地平和尼莫地平的给药引起的行为和镇痛作用。

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Evidence exists that calcium antagonists can have effects on neural function. The aim of this work is to analyze the effect of two dihydropyridines, nifedipine and nimodipine, administered for 11 days on the behavior and pain sensitivity of rats. Nociception was tested using the tail electric stimulation test, and behavior parameters using a holeboard. Our results show that chronic administration of nifedipine or nimodipine induces analgesia that can be evaluated by tail withdrawal. However, neither the vocalization nor the vocalization after discharge were modified, so the analgesia may be mediated by spinal mechanisms. Rats treated with nifedipine or nimodipine exhibited a dose-dependent tendency to avoid the center of the field without modification of other parameters, suggesting an increased emotivity in the rats. This conclusion is supported by the fact that anxiogenic or anxiolytic drugs modify the pattern of locomotion without significant changes in other parameters related with the motility. The results from this study suggest the view of a complex mechanism of action underlying nifedipine- and nimodipine-mediated behavioral effects.
机译：有证据表明钙拮抗剂可以影响神经功能。这项工作的目的是分析施用11天的两种二氢吡啶（硝苯地平和尼莫地平）对大鼠行为和疼痛敏感性的影响。使用尾部电刺激测试测试伤害感受，并使用孔板测试行为参数。我们的结果表明，硝苯地平或尼莫地平的长期给药可引起镇痛作用，可通过撤尾来评估镇痛作用。但是，发声和出院后的发声都没有改变，因此镇痛可能是由脊柱机制介导的。用硝苯地平或尼莫地平治疗的大鼠表现出剂量依赖性的趋势，可以在不改变其他参数的情况下避开磁场中心，这表明大鼠的动力增加。这一结论得到以下事实的支持：抗焦虑药或抗焦虑药可以改变运动方式，而与运动性相关的其他参数却没有明显变化。这项研究的结果表明，硝苯地平和尼莫地平介导的行为作用具有复杂的作用机制。

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