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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Selective blockade of spontaneous motor stereotypy via intrastriatal pharmacological manipulation.
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Selective blockade of spontaneous motor stereotypy via intrastriatal pharmacological manipulation.

机译：通过纹状体内药物操纵选择性阻断自发性运动刻板印象。

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摘要

Abnormal repetitive behavior, including stereotypy, is often observed in conjunction with developmental, neuropsychiatric, and genetic disorders. The present work employed the deer mouse model of spontaneous and persistent stereotypy to identify basal ganglia involvement in the mediation of these abnormal behaviors. To evaluate the hypothesis that stereotypy is expressed in these mice due to alterations in the activity of cortico-basal ganglia motor circuits, intrastriatal pharmacological manipulations aimed at attenuating the spontaneously emitted stereotypy were performed. Bilateral striatal infusion of the NMDA or dopamine D(1) receptor antagonists MK-801 or SCH23390, respectively, produced a substantial reduction in levels of stereotypic jumping without inhibiting nonstereotypic motor behavior. These findings support the hypothesis that environmentally related stereotypy is expressed as a consequence of elevated feedback activity occurring along motor circuits of the basal ganglia.
机译：通常会与发育，神经精神病和遗传性疾病一起观察到异常的重复行为，包括定型观念。本工作采用自发性和持续性刻板印象的鹿小鼠模型来鉴定基底神经节参与这些异常行为的介导。为了评估在这些小鼠中由于皮质-基底神经节运动回路的活性改变而导致刻板印象的假设，进行了旨在减弱自发性刻板印象的纹状体内药理操作。 NMDA或多巴胺D（1）受体拮抗剂MK-801或SCH23390的双侧纹状体输注分别在不抑制非定型运动行为的情况下，大大减少了定型跳跃的水平。这些发现支持这样的假说，即与环境有关的刻板印象是由于沿基底神经节的运动回路发生的反馈活动增加而引起的。

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