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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol effects on three strains of zebrafish: model system for genetic investigations.
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Ethanol effects on three strains of zebrafish: model system for genetic investigations.

机译：乙醇对三种斑马鱼品系的影响：遗传研究模型系统。

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摘要

The effects of acute and chronic ethanol administration on the wild-type (WT), long-fin striped (LFS), and blue long-fin (BLF) strains of zebrafish were investigated. In the LFS strain, acute exposure to 0.25% (v/v) ethanol inhibited the startle reaction and increased both the area occupied by a group of subjects and the average distance between each fish and its nearest neighbor. Similar effects were found in the WT fish although higher concentrations of ethanol were required. No effects on the behavior of the BLF fish were observed with up to 1.0% (v/v) ethanol. Brain alcohol levels were comparable among the three strains precluding a pharmacokinetic explanation for the behavioral results. In LFS zebrafish, behavioral tolerance was observed after 1 week of continual exposure to ethanol. Conversely, chronic ethanol exposure of the WT fish for up to 2 weeks did not result in the development of tolerance, but rather appeared to increase the disruptive action of the drug. The present results suggest the observed strain differences in the effects of ethanol reflect genotypic differences in both the response of the central nervous system (CNS) to ethanol as well as the ability of the CNS to adapt to ethanol exposure. Although preliminary, the present study indicates that the zebrafish is an excellent model system to investigate the genetic determinants involved in regulating the responses to ethanol.
机译：研究了急性和慢性乙醇施用对斑马鱼的野生型（WT），长鳍条纹（LFS）和蓝色长鳍（BLF）菌株的影响。在LFS品系中，急性暴露于0.25％（v / v）的乙醇会抑制惊吓反应，并增加一组对象占据的面积以及每条鱼与其最近邻居之间的平均距离。尽管需要更高浓度的乙醇，但在野生鱼类中也发现了类似的效果。观察到高达1.0％（v / v）乙醇对BLF鱼的行为没有影响。在这三种菌株中，脑酒精水平相当，从而排除了对行为结果的药代动力学解释。在LFS斑马鱼中，连续暴露于乙醇1周后观察到行为耐受。相反，野生型鱼类长达2周的慢性乙醇暴露并没有导致耐受性的发展，反而似乎增加了药物的破坏作用。目前的结果表明，观察到的乙醇作用中的菌株差异反映了中枢神经系统（CNS）对乙醇的反应以及CNS适应乙醇暴露的能力的基因型差异。尽管是初步的，但本研究表明斑马鱼是研究涉及调节对乙醇反应的遗传决定因素的优秀模型系统。

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