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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prolonged perinatal AZT administration and early maternal separation: effects on social and emotional behaviour of periadolescent mice.
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Prolonged perinatal AZT administration and early maternal separation: effects on social and emotional behaviour of periadolescent mice.

机译：延长围产期AZT给药和早期母体分离：对青春期小鼠社交和情感行为的影响。

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Zidovudine (AZT) is an effective treatment in preventing perinatal transmission of HIV-1; however, a continuous re-evaluation of the risk-benefit ratio of human exposure to this drug is suggested by both clinical and animal studies. The objective of this study was to assess the medium and long-term effects of pre-postnatal AZT treatment on mouse social and emotional behaviour and the possible interactions between AZT exposure and disruptions in the mother-infant relationship. Pregnant CD-1 mice were administered per os with AZT (160 mg/kg) from pregnancy day 10, throughout delivery, to lactation day 10. In half of the litters, the offspring was separated from the mother for 3 h from postnatal days 2 (PND2) to PND14. On PND35, a 30-min social interaction test was performed and corticosterone levels were measured at the end of the session. On PND80, long-term effects of AZT on emotionality were assess by means of an elevated plus-maze. Results indicate that, on PND35, previous AZT exposure affected social behaviour of the experimental subjects, reducing aggressive interactions in males, while decreasing investigative behaviours in females. At adulthood, AZT inhibited exploratory behaviour in the plus-maze while increasing the frequency of risk-assessment postures in male mice. As for maternal deprivation, this early manipulation exerted a pro-aggressive effect in adolescent male mice, deprived subjects being overall characterised by higher activity levels and a deficit in habituation, an effect also observed in the plus-maze. A significant interaction between AZT and maternal deprivation was found for affiliative behaviours. As for corticosterone levels, no AZT effect was found, while maternal deprivation tended to reduce elevations of this hormone in response to stressful stimuli. Overall results from this study indicate that both AZT exposure and maternal deprivation induced gender-dependent changes in social and emotional behaviour both during adolescence and at adulthood.
机译：齐多夫定（AZT）是预防围产期HIV-1传播的有效方法;然而，临床和动物研究均建议对人类接触该药物的风险-收益比进行连续的重新评估。这项研究的目的是评估产前AZT治疗对小鼠社交和情绪行为的中长期影响，以及AZT暴露与母婴关系中断之间的可能相互作用。从怀孕第10天到分娩第10天，分别对怀孕的CD-1小鼠进行口服AZT（160 mg / kg）口服，在出生后的第3天中，在一半的产仔中，其后代与母亲分开3 h。 （PND2）至PND14。在PND35上，进行了3​​0分钟的社交互动测试，并在会议结束时测量了皮质酮水平。在PND80上，通过高迷宫评估AZT对情绪的长期影响。结果表明，在PND35上，以前的AZT暴露会影响实验对象的社会行为，减少男性的攻击性互动，同时减少女性的调查行为。在成年期，AZT抑制了迷宫中的探索行为，同时增加了雄性小鼠风险评估姿势的频率。至于母体剥夺，这种早期的操纵在青春期雄性小鼠中发挥了积极的攻击作用，被剥夺的受试者总体上具有较高的活动水平和习惯性缺陷的特征，这种效应在正迷宫中也观察到。 AZT与母体剥夺之间的显着相互作用被发现是从属行为。至于皮质类固醇水平，没有发现AZT效应，而母体剥夺往往会在压力刺激下降低这种激素的升高。这项研究的总体结果表明，AZT暴露和母体剥夺都在青春期和成年期引起了社会和情感行为中性别依赖性的变化。

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