Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna Disease Virus.

Solbrig MV; Koob GF

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Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna Disease Virus.

机译：持续中枢神经系统病毒感染的神经药理后遗症：来自博尔纳病病毒的经验教训。

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Borna Disease Virus (BDV) is a neurotropic RNA virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species. BDV has also been reported to be associated with neuropsychiatric diseases of humans by serologic study and by recovery of nucleic acid or virus from blood or brain. Natural infections of horses and sheep produce encephalitis with erratic excited behaviors, hyperkinetic movement or gait abnormalities; naturally infected cats have ataxic "staggering disease." Experimentally infected primates develop hyperactivity, aggression, disinhibition, then apathy; prosimians (lower primates) have hyperactivity, circadian disruption, abnormal social and dominance behaviors, and postural disorders. However, the neuropharmacological determinants of BD phenotypes in laboratory and natural hosts are incompletely understood. Here we review how experimentally infected rodents have provided models for examining behavioral, pharmacologic, and biochemical responses to viral challenge, and how rodents experimentally infected as neonates or as adolescents are providing models for examining age-specific neuropharmacological adaptations to viral injury.

机译：博尔纳病病毒（BDV）是一种神经营养性RNA病毒，在全世界范围内分布广泛，会引起多种动物的运动和行为障碍。据报道，通过血清学研究以及从血液或大脑中回收核酸或病毒，BDV与人类的神经精神疾病有关。马和绵羊的自然感染会导致脑炎，并表现出不稳定的兴奋行为，运动过度或步态异常;自然感染的猫患有共济失调的“惊人疾病”。经实验感染的灵长类动物会产生过度活跃，攻击性，抑制性，然后变得冷漠。猿猴（低等灵长类动物）活动过度，昼夜节律紊乱，社交和主导行为异常以及姿势异常。但是，尚不完全了解实验室和自然宿主中BD表型的神经药理学决定因素。在这里，我们回顾了实验性感染的啮齿动物如何为检查病毒攻击的行为，药理和生化反应提供模型，以及实验性地感染新生或青春期的啮齿动物如何为检查针对病毒损伤的特定年龄神经药理学适应性提供模型。

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《Pharmacology, Biochemistry and Behavior》 |2003年第4期|共11页
作者
Solbrig MV; Koob GF;
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正文语种 eng
中图分类药学;
关键词
Virus; Borna Disease; BDV; Viral; Borna病;

机译：Virus;Borna Disease;BDV;Viral;Borna病;

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1. Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna Disease Virus. [J] . Solbrig MV, Koob GF Pharmacology, Biochemistry and Behavior . 2003,第4期

机译：持续中枢神经系统病毒感染的神经药理后遗症：来自博尔纳病病毒的经验教训。
2. Learning deficits in mice with persistent Borna disease virus infection of the CNS associated with elevated chemokine expression. [J] . Sauder C, Wolfer DP, Lipp HP, Behavioural Brain Research: An International Journal . 2001,第2期

机译：患有持续性博尔纳病病毒感染中枢神经系统的小鼠的学习缺陷与趋化因子表达升高有关。
3. Experimental induction of mucosal disease: consequences of superinfection of persistently infected cattle with different strains of cytopathogenic bovine viral diarrhea virus. [J] . Loehr BI, Frey HR, Moennig V, Archives of virology . 1998,第4期

机译：实验性粘膜疾病的诱导：持续感染牛的致病性牛病毒性腹泻病毒不同株的重复感染的后果。
4. THE ADVANTAGE OF PERSISTENT VIRAL INFECTIONS (VIRAL ACCOMMODATION) IN CRUSTACEANS AND OTHER ARTHROPODS [C] . T.W. Flegel International Conference of the European Aquaculture Society . 2004

机译：甲壳类动物和其他节肢动物中持续性病毒感染（病毒型住院）的优势
5. The role of CXCL9 in host defense during acute viral infection of the CNS and liver in mice: Perspectives using a recombinant mouse hepatitis virus. [D] . Muse, Michael Harold. 2007

机译：CXCL9在小鼠中枢神经系统和肝脏的急性病毒感染过程中在宿主防御中的作用：使用重组小鼠肝炎病毒的观点。
6. Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus. [O] . D Gonzalez-Dunia, M Eddleston, N Mackman, 1996

机译：在持续感染天疱疮病毒的过程中中枢神经系统星形胶质细胞中组织因子的表达增加。
7. The mechanism of persistent infection and pathogenesis of Borna disease virus. [O] . Keizo Tomonaga 2003

机译：持续性感染和纵向疾病病毒发病机制的机制。

Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna Disease Virus.

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