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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon.
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Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon.

机译：与三唑酮类杀菌剂有关的行为敏化和长期神经化学改变。

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Triadimefon (TDF), a widely used triazole fungicide, blocks reuptake of the neurotransmitter dopamine (DA), similarly to cocaine. Preliminary studies show that intermittent intraperitoneal injections of TDF increase ambulatory and vertical activity across repeated injections [Neurotoxicology (in press)] leading to the hypothesis tested here, that exposure to TDF may influence the development and expression of behavioral sensitization, a model of psychostimulant-induced psychosis. Exposure of adult male C57BL/6 mice to 75 mg/kg i.p. TDF (TDF75) twice a week for 7 weeks increased vertical activity at each injection. Following a 2-week withdrawal period, a TDF challenge to test for expression of behavioral sensitization revealed further increases in vertical activity levels relative to all other conditions. TDF induction/expression of behavioral sensitization was associated with long-term, perhaps permanent modulation of dopaminergic function that included increases in striatal dihydroxyphenylacetic acid (DOPAC) and DA turnover, increases in medial prefrontal cortex (mPFC) dopamine transporter (DAT) binding, as well as decreases in DA D1 and increases in DA D2 and DAT receptor binding that appeared to target the nucleus accumbens shell (NAs) subregion. Thus, TDF exposure may serve as an environmental risk factor for DA system dysfunctions.
机译：三唑酮（TDF）是一种广泛使用的三唑类杀菌剂，与可卡因类似，它能阻止神经递质多巴胺（DA）的再摄取。初步研究表明，间歇性TDF腹膜内注射可增加反复注射的动态和垂直活动[神经毒理学（印刷中）]，从而得出假设，此处的假设是，暴露于TDF可能会影响行为敏化的发展和表达，这是一种心理刺激模型。诱发精神病。成年雄性C57BL / 6小鼠腹膜内暴露于75 mg / kg TDF（TDF75）每周两次，持续7周，每次注射时增加垂直活动。停药2周后，进行行为敏化表达测试的TDF攻击显示相对于所有其他条件，垂直活动水平进一步增加。 TDF诱导/行为敏化的表达与多巴胺能功能的长期（可能是永久性）调节有关，其中包括纹状体二羟苯基乙酸（DOPAC）和DA转换的增加，内侧额叶前皮层（mPFC）多巴胺转运蛋白（DAT）结合的增加，例如以及DA D1的减少以及DA D2和DAT受体结合的增加，这些结合似乎靶向伏伏核壳（NAs）子区域。因此，TDF暴露可能成为DA系统功能障碍的环境危险因素。

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