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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of Hypericum perforatum and paroxetine in the mouse defense test battery.
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Effects of Hypericum perforatum and paroxetine in the mouse defense test battery.

机译：贯叶连翘和帕罗西汀在小鼠防御试验电池中的作用。

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Since (a) Hypericum perforatum shows anxiolytic-like effect in some animal models, (b) antidepressant drugs (AD) have been used as the main drug treatment for panic disorder (PD), (c) AD are also effective in generalized anxiety disorder (GAD), and (d) H. perforatum exhibits antidepressant activity, it was hypothesized that H. perforatum might possess an antipanic-like and/or anxiolytic-like effect. Previous studies with the mouse defense test battery (MDTB) have suggested that this model may be useful for the investigation of anxiolytic-like and antipanic-like compounds. Thus, the aim of the present study was to evaluate the effect of H. perforatum extract in the MDTB. The effect of acute, subchronic (7 days), and chronic (21 days) H. perforatum (150 and 300 mg/kg) extract administration was evaluated in mice submitted to the MDTB. Paroxetine (5 mg/kg), a selective serotonin re-uptake inhibitor with anxiolytic and antipanic effect, was used as a positive control. The results showed that 21 days of repeated administration of H. perforatum 300 mg/kg and paroxetine 5 mg/kg reduced flight reactions (number of avoidances, avoidance distance, and overall flight speed) to the presence of the predator. While the effect of paroxetine confirms that MDTB is useful for the detection of antipanic-like drugs, the effect of H. perforatum suggests a putative antipanic-like effect for this extract. Moreover, after 21 days of repeated administration, paroxetine increased the number of approaches/withdrawals and reduced the number of upright postures, suggesting a partial anxiolytic-like effect, while H. perforatum only reduced the number of upright postures. The present results suggest anxiolytic-like and antipanic-like effects of H. perforatum extract. However, it should be emphasized that the risk assessment (the main index of anxiety) was not affected by the extract, while the attack reactions were only weakly modified.
机译：由于（a）贯叶连翘在某些动物模型中表现出抗焦虑样作用，（b）抗抑郁药（AD）已被用作恐慌症（PD）的主要药物治疗，（c）AD在广泛性焦虑症中也有效（GAD）和（d）贯叶连翘具有抗抑郁活性，据推测，贯叶连翘可能具有抗惊恐样和/或抗焦虑样作用。先前使用鼠标防御测试电池（MDTB）进行的研究表明，该模型可能对研究抗焦虑药和抗惊恐药有用。因此，本研究的目的是评估贯叶连翘提取物在MDTB中的作用。在提交给MDTB的小鼠中评估了穿孔，贯叶连翘（150和300 mg / kg）提取物的急性，亚慢性（7天）和慢性（21天）的作用。帕罗西汀（5 mg / kg）是一种具有抗焦虑和抗惊恐作用的选择性5-羟色胺再摄取抑制剂，被用作阳性对照。结果表明，重复服用贯叶连翘300 mg / kg和帕罗西汀5 mg / kg的21天可减少捕食者存在的飞行反应（避免次数，避免距离和总体飞行速度）。虽然帕罗西汀的作用证实了MDTB可用于检测类惊恐药，但贯叶连翘的作用表明该提取物具有假定的类惊恐作用。此外，在重复给药21天后，帕罗西汀增加了进/退出次数，并减少了直立姿势的数量，这表明存在部分抗焦虑药作用，而穿孔杆菌仅减少了直立姿势的数量。目前的结果表明，贯叶连翘提取物具有抗焦虑和抗惊恐作用。但是，应该强调的是，风险评估（焦虑的主要指标）不受提取物的影响，而攻击反应仅被弱化了。

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