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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Moderate doses of ethanol partially reverse avoidance learning deficits in high-alcohol-drinking rats.
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Moderate doses of ethanol partially reverse avoidance learning deficits in high-alcohol-drinking rats.

机译：适量的乙醇可以部分逆转高饮酒大鼠的回避学习缺陷。

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We previously reported that ethanol-naive high-alcohol-drinking (HAD1 and HAD2) rats exhibited selective deficits in active avoidance learning, as compared to low-alcohol-drinking (LAD1 and LAD2) rats, in a signaled bar-pressing task [Alcohol. Clin. Exp. Res. 24 (2000) 1778]. In the current study, we used appetitive and aversive learning tasks to assess whether administration of ethanol influences approach and avoidance learning in HAD and LAD rats. Rats were administered 0.0, 0.5, 1.0, or 1.5 g ethanol/kg body weight during appetitive and aversive conditioning sessions. We found that ethanol impaired acquisition of the appetitive conditioned response in a dose-dependent manner in both HAD and LAD rats, with 1.5 g/kg ethanol producing the greatest deficits. Notably, moderate doses of ethanol (0.5 and 1.0 g/kg) partially reversed avoidance learning deficits in HAD rats, but only when appetitive conditioning preceded aversive conditioning. The highest dose (1.5 g/kg EtOH) abolished avoidance responding altogether in HAD rats. Avoidance responding in LAD rats was not affected by any dose of ethanol. These results are consistent with previous studies suggesting that alcohol preference may be associated with increased fear or anxiety, but the conditions under which ethanol produces a reduction of fear and anxiety in HAD rats appear to be relatively complex.
机译：我们以前曾报道过，与低酒精饮料（LAD1和LAD2）大鼠相比，无酒精高酒精饮料（HAD1和HAD2）大鼠在主动回避学习中表现出选择性的缺陷，这在信号指示压迫任务[Alcohol 。临床经验Res。 24（2000）1778]。在当前的研究中，我们使用了竞争性和厌恶性学习任务来评估乙醇的施用是否会影响HAD和LAD大鼠的进近和回避学习。在食性和厌恶性调节阶段中，大鼠以0.0、0.5、1.0或1.5 g乙醇/ kg体重的剂量服用。我们发现在HAD和LAD大鼠中，乙醇以剂量依赖的方式损害了获得性条件性反应的获取，其中1.5 g / kg乙醇产生最大的赤字。值得注意的是，适量的乙醇（0.5和1.0 g / kg）可以部分逆转HAD大鼠的回避学习障碍，但前提是在有条件的调适先于厌恶的调适之前。在HAD大鼠中，最高剂量（1.5 g / kg乙醇）完全避免了避免反应。 LAD大鼠的回避反应不受任何剂量乙醇的影响。这些结果与先前的研究一致，表明酒精偏好可能与恐惧或焦虑增加有关，但是乙醇在HAD大鼠中产生恐惧和焦虑减轻的条件似乎相对复杂。

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