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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat.
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Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat.

机译：尼古丁引起的大鼠脑皮质神经活性类固醇和血浆皮质酮浓度的变化。

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摘要

Nicotine, one of the most widely used psychotropic substances, is able to induce both anxiolytic and anxiogenic effects. The effect of this drug on the brain and plasma concentrations of neuroactive steroids was examined in the rat. Anxiolytic doses of nicotine (0.03-0.3 mg/kg) had no significant effect, whereas administration of anxiogenic doses (0.5 to 2 mg/kg) produced a dose- and time-dependent increase in the cerebrocortical concentrations of pregnenolone, progesterone, and allopregnanolone, with the greatest observed effects (+180%, +223%, and +124%, respectively) apparent at the dose of 2 mg/kg. In contrast, nicotine (1-2 mg/kg) decrease by 31% and 38%, respectively, the concentration of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone, or THDOC) in the cerebral cortex. Nicotine also increased the plasma concentrations of pregnenolone and progesterone, whereas failed to affect significantly those of allopregnanolone or THDOC. Nicotine induced a dose- and time-dependent increase in the plasma concentration of corticosterone, indicating that this drug activates the hypothalamic-pituitary-adrenal (HPA) axis. These results suggest that the changes in emotional behavior elicited by nicotine, similar to those induced by stressful stimuli or other anxiogenic drugs, are associated with an increase in neuroactive steroids content of the brain.
机译：尼古丁是最广泛使用的精神药物之一，能够诱导抗焦虑和抗焦虑作用。在大鼠中检查了这种药物对大脑和血浆中神经活性类固醇浓度的影响。尼古丁的抗焦虑剂量（0.03-0.3 mg / kg）没有明显作用，而给予抗焦虑药的剂量（0.5至2 mg / kg）会使孕烯醇酮，孕酮和去甲肾上腺素的脑皮质浓度呈剂量和时间依赖性增加。 ，在2 mg / kg的剂量下，观察到的效应最大（分别为+180％，+ 223％和+ 124％）。相比之下，尼古丁（1-2 mg / kg）分别降低了大脑皮层中3alpha，21-dihydroxy-5alpha-pregnan-20-one（allotetrahydrodeoxycorticosterone或THDOC）的浓度31％和38％。尼古丁还增加了孕烯醇酮和孕酮的血浆浓度，而未能显着影响阿洛培那那龙或THDOC的血药浓度。尼古丁引起皮质酮血浆浓度的剂量和时间依赖性增加，表明该药激活了下丘脑-垂体-肾上腺（HPA）轴。这些结果表明，尼古丁引起的情绪行为的变化与压力刺激或其他焦虑药引起的变化相似，与大脑神经活性类固醇含量的增加有关。

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