• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Adaptogenic effect of Bacopa monniera (Brahmi).
【24h】

Adaptogenic effect of Bacopa monniera (Brahmi).

机译：Bacopa monniera（Brahmi）的适应原性作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As stress is linked to many diseases, research on an effective antistress agent (adaptogen) from plants has gained importance. We report the investigations on the adaptogenic property of a standardized extract of Bacopa monniera against acute (AS) and chronic stress (CS) models in rats. Panax root powder (Panax quinquefolium) was taken as a standard. Male SD rats, weighing 180-200 g, exposed to immobilization stress for 150 min once only for AS and for seven consecutive days in CS, were fed with B. monniera or Panax root powder daily for 3 days in AS and for 7 days in CS, 45 min prior to each exposure of stress. Rats were sacrificed immediately after stress, the blood was collected, and the plasma was separated out for biochemical estimation. Adrenals, spleen, and thymus were dissected for organ weight and stomach for ulcer score. AS exposure significantly increased the ulcer index, adrenal gland weight, plasma glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) but significantly decreased the spleen weight. Pretreatment with B. monniera at 40 mg/kg po significantly reduced the AS-induced increase in the ulcer index, adrenal gland weight, plasma glucose, AST, and CK. A dose of 80 mg/kg po significantly reversed the AS-induced changes in adrenal gland weight, spleen weight, plasma glucose, ALT, and AST. Panax root powder, 100 mg/kg po, significantly reversed the AS-induced changes in spleen weight, plasma ALT, AST, and CK. CS exposure resulted in a significant increase in the ulcer index, adrenal gland weight, plasma AST, and CK with a significant decrease in the thymus and spleen weight, plasma triglyceride, and cholesterol. Pretreatment with low dose of B. monniera extract at 40 mg/kg significantly reversed changes in ulcer index and plasma AST only, whereas the pretreatment with higher dose significantly reversed CS-induced changes in ulcer index, adrenal gland weight, CK, and AST. Panax root powder significantly reversed CS-induced increase in ulcer index, adrenal gland weight, CK, and AST. On the basis of our result, it is concluded that the standardized extract of B. monniera possesses a potent adaptogenic activity.
机译：由于压力与许多疾病有关，因此研究植物有效的抗应激剂（适应原）变得非常重要。我们报告调查的Bacopa monniera标准提取物对大鼠的急性（AS）和慢性应激（CS）模型的适应性研究。以人参根粉（Panax quinquefolium）为标准。雄性SD大鼠，体重180-200 g，仅在AS中一次暴露于固定压力下150分钟，并在CS中连续7天，每天在AS中饲喂B. monniera或人参根粉3天，在AS中连续7天。 CS，每次暴露压力前45分钟。应激后立即处死大鼠，收集血液，并分离血浆以进行生化评估。解剖肾上腺，脾脏和胸腺的器官重量和胃溃疡分数。 AS暴露显着增加溃疡指数，肾上腺重量，血浆葡萄糖，丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST）和肌酸激酶（CK），但显着降低脾脏重量。用40 mg / kg po的B. monniera预处理可显着降低AS诱导的溃疡指数，肾上腺重量，血浆葡萄糖，AST和CK的升高。口服80 mg / kg剂量可显着逆转AS诱导的肾上腺重量，脾脏重量，血浆葡萄糖，ALT和AST的变化。人参根粉100 mg / kg po，可显着逆转AS诱导的脾脏重量，血浆ALT，AST和CK的变化。 CS暴露导致溃疡指数，肾上腺重量，血浆AST和CK显着增加，而胸腺和脾脏重量，血浆甘油三酸酯和胆固醇显着降低。以40 mg / kg的剂量进行低剂量的羊膜芽孢杆菌提取物预处理可以显着逆转溃疡指数和血浆AST的变化，而以高剂量进行预处理可以显着逆转CS诱导的溃疡指数，肾上腺重量，CK和AST的变化。人参根粉可显着逆转CS诱导的溃疡指数，肾上腺重量，CK和AST的增加。根据我们的结果，可以得出结论，该菌株的标准化提取物具有强大的适应原活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号