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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Serotonergic-dopaminergic mediation of MDMA's discriminative stimulus effects in a three-choice discrimination.
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Serotonergic-dopaminergic mediation of MDMA's discriminative stimulus effects in a three-choice discrimination.

机译：MDMA的歧视性刺激作用的血清素-多巴胺能介导的三选区分。

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摘要

(+/-)3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") is a common drug of abuse that is often described as both a psychostimulant and a hallucinogen. Two-choice drug discriminations (i.e. drug vs. nondrug) in nonhumans comparing the discriminative stimulus properties of MDMA to psychostimulants or hallucinogens have produced somewhat inconsistent findings. The relative contribution of serotonergic versus dopaminergic actions to MDMA's discriminative stimulus effects may depend on the training stimulus conditions employed. We have previously demonstrated that rats can learn to discriminate the effects of MDMA and D-amphetamine in a three-choice drug discrimination procedure, and that LSD produced nearly complete substitution for MDMA under these conditions, and fenfluramine fully substituted for MDMA. In the present study, 12 rats were trained to discriminate LSD (0.08 mg/kg) and MDMA (1.5 mg/kg) from saline in a three-choice drug discrimination procedure under a fixed-ratio (FR) 10 schedule of food reinforcement. D-Amphetamine produced only partial substitution for MDMA while fenfluramine produced complete stimulus generalization. Low doses of D-amphetamine and fenfluramine produced greater stimulus generalization when administered in combination than when given alone. The serontonin(2) antagonist MDL-100,907 only partially blocked the MDMA cue, but completely antagonized LSD discrimination. The dopamine antagonist haloperidol also failed to block MDMA discrimination. These results indicate that 5-HT release is a salient feature to MDMA's discriminative stimulus effects but that MDMA produces a compound discriminative stimulus.
机译：（+/-）3，4-亚甲基二氧基甲基苯丙胺（MDMA;“摇头丸”）是一种常见的滥用药物，通常被描述为一种精神兴奋剂和一种致幻剂。在非人类中将MDMA与精神刺激药或致幻剂的歧视性刺激性质进行比较的非人选择药物歧视（即毒品与非毒品）产生了一些不一致的发现。血清素能和多巴胺能对MDMA的歧视性刺激作用的相对贡献可能取决于所采用的训练刺激条件。先前我们已经证明，大鼠可以通过三选药物区分程序学习区分MDMA和D-苯异丙胺的作用，并且LSD在这些条件下几乎可以完全替代MDMA，而芬氟拉明可以完全替代MDMA。在本研究中，训练了12只大鼠，按照三选择药物鉴别程序，按照固定比例（FR）10的食品强化时间表，从盐水中区分LSD（0.08 mg / kg）和MDMA（1.5 mg / kg）。 D-苯丙胺仅产生部分取代MDMA，而芬氟拉明则产生完全的刺激泛化。与单独给药相比，低剂量的D-苯丙胺和芬氟拉明产生更大的刺激泛化作用。血清素（2）拮抗剂MDL-100,907仅部分阻断了MDMA信号，但完全拮抗了LSD歧视。多巴胺拮抗剂氟哌啶醇也不能阻断MDMA的鉴别。这些结果表明5-HT释放是MDMA的歧视性刺激作用的一个显着特征，但MDMA会产生复合的歧视性刺激。

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