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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of postnatal PCP treatment on locomotor behavior and striatal D(2) receptor.
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Effects of postnatal PCP treatment on locomotor behavior and striatal D(2) receptor.

机译：产后PCP治疗对运动行为和纹状体D（2）受体的影响。

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摘要

Exposing the developing brain to the N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) has been shown to cause deficits in neurobehavioral functions, particularly on learning and memory and seizure sensitivity. Besides acting as a noncompetitive NMDA antagonist, PCP at high doses is known to affect the dopaminergic system. The present study assessed the effect of postnatal PCP treatment on locomotor activity and striatal dopamine (DA) D(2) receptor. Male and female rat pups were injected intraperitoneally (ip) with one of three doses of PCP (1, 3 and 5 mg/kg) or saline from postnatal day (PD) 5 to PD 15. Control and PCP-treated rats were given a challenge dose of PCP (10 mg/kg) as adults, and their locomotor behaviors-locomotion, stereotypy and ataxia-were scored. Postnatal PCP treatment did not have any significant effect in either sex on any of the PCP-induced locomotor behavioral paradigms studied. Separate groups of male and female rats were treated daily with saline or PCP (5 mg/kg ip) from PD 5 to PD 15 and sacrificed either as juveniles (PD 21) or adults, and D(2) receptor binding was measured in their striata. Striatal D(2) receptor density in juvenile and adult male postnatal PCP-treated rats did not differ from saline-treated controls. Adult female PCP-treated rats showed a slight but significant reduction in the maximal binding of striatal D(2) receptors. There was no effect of postnatal PCP on striatal D(2) receptor binding in female juvenile rats. These results support the hypothesis that blocking the developing NMDA receptor minimally affects PCP-induced locomotor behavior and the striatal D(2) receptor.
机译：研究表明，将发育中的大脑暴露于N-甲基-D-天冬氨酸（NMDA）受体拮抗剂苯环利定（PCP）会导致神经行为功能缺陷，特别是在学习和记忆以及癫痫发作敏感性方面。除了充当非竞争性NMDA拮抗剂外，高剂量的PCP还可以影响多巴胺能系统。本研究评估了产后PCP治疗对运动活动和纹状​​体多巴胺（DA）D（2）受体的影响。从出生后第5天到第15天，分别给雄性和雌性幼鼠腹膜内（ip）注射三剂PCP（1、3和5 mg / kg）或生理盐水之一，对照组和PCP处理的大鼠接受腹膜内注射。对成人的PCP激发剂量（10 mg / kg）及其运动行为（运动，刻板印象和共济失调）进行了评分。产后五氯苯酚治疗对所研究的五氯苯酚诱发的运动行为范例均无明显影响。每天分别用PD 5至PD 15的生理盐水或五氯苯酚（5 mg / kg ip ip）处理雄性和雌性大鼠的不同组，以幼年（PD 21）或成年时处死，并测量其D（2）受体结合纹状体。幼年和成年雄性产后PCP治疗大鼠的纹状体D（2）受体密度与生理盐水治疗的对照无差异。成年雌性PCP治疗的大鼠显示纹状体D（2）受体的最大结合略有但明显减少。产后PCP对雌性幼年大鼠纹状体D（2）受体的结合没有影响。这些结果支持一个假设，即阻止发育中的NMDA受体对PCP诱导的运动行为和纹状体D（2）受体的影响最小。

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